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FACT-L

Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility

November 17, 2011 - 13:32 -- Patrick Sampao
Author(s): 
Eliane C. Laurentino, Sonya Taylor, Andrew P. Waters, et al.
Reference: 
Cellular Microbiology, Volume 13, Issue 12, pages 1956–1974, December 2011

MalariaWorldWe identified a Plasmodium berghei protein, termed FACT-L, with homology to the SPT16 subunit of FACT. Epitope tagging of FACT-L showed nuclear localization with high expression in the nuclei of (activated) male gametocytes.

Medical Condition: 
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