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P52

Short Report: Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

October 27, 2011 - 14:41 -- Open Access
Author(s): 
Bruno Douradinha, Melissa van Dijk, Sabrina Epiphanio, et al.
Reference: 
Journal of Immune Based Therapies and Vaccines 2011, 9:6

MalariaWorldWe demonstrate that immunization with p52-GAP sporozoites also results in a strong increase of effector memory CD8+ T cells, even 6 months after immunization, whereas no specific CD4+ effector T cells response could be detected. In addition, we show that the increase of effector memory CD8+ T cells is specific for the liver and not for the spleen or lymph nodes.

 

Medical Treatment: 
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