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Cerebral Malaria

Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria

November 12, 2012 - 08:20 -- Open Access
Author(s): 
Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A. Mikolajczak, Stefan H. I. Kappe, Ute Frevert
Reference: 
PLoS Pathog 8(10): e1002982
MalariaWorld

Plasmodium falciparum malaria is responsible for nearly one million annual deaths worldwide.

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NOT Open Access | Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria

October 16, 2012 - 06:52 -- Kabogo Ndegwa
Author(s): 
T. N. Ramos, D. C. Bullard and S. R. Barnum
Reference: 
Parasite Immunology, Volume 34, Issue 11, pages 547–550, November 2012

MalariaWorldComplement receptors for C3-derived fragments (CR1–4) play critical roles in innate and adaptive immune responses.

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NOT Open Access | Deletion of carboxypeptidase N delays onset of experimental cerebral malaria

August 8, 2012 - 06:51 -- Kabogo Ndegwa
Author(s): 
M. M. Darley, T. N. Ramos, R. A. Wetsel, S. R. Barnum
Reference: 
Parasite Immunology, Volume 34, Issue 8-9, pages 444–447, August/September 2012

MalariaWorldComplement contributes to inflammation during pathogen infections; however, less is known regarding its role during malaria and in the severest form of the disease, cerebral malaria.

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Not Open Access | Blood group phenotypes A and B are risk factors for cerebral malaria in Odisha, India

August 6, 2012 - 14:23 -- Patrick Sampao
Author(s): 
Ronnaly Rout, Gunanidhi Dhangadamajhi, Milan Ghadei, Biranchi N. Mohapatra, Shantanu K. Kar, Manoranjan Ranjit
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, Issue 9, September 2012, Pages 538-543

MalariaWorldThe results showed high prevalence of blood group B in both mild (n = 110) and severe malaria (cerebral malaria [CM]; n = 130 and non-cerebral severe malaria [NCSM]; n = 103) categories among the non-O group and while type O is significantly associated with protection against CM, patients with type A and B group had increased risk for developing CM.

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Not Open Access | Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase acitivity in the hippocampus of survivor mice

August 1, 2012 - 13:08 -- Patrick Sampao
Author(s): 
Clarissa M. Comim, Patrícia A. Reis, Hugo C. Castro-Faria-Neto, et al.
Reference: 
Neuroscience Letters, Volume 523, Issue 2, 15 August 2012, Pages 104–107

MalariaWorldIn the present work, we evaluated BDNF protein levels and AChE activity in the hippocampus and habituation in an animal model of CM using C57BL/6 mice after fifteen days of the induction.

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Distinct placental malaria pathology caused by different Plasmodium berghei lines that fail to induce cerebral malaria in the C57Bl/6 mouse

July 20, 2012 - 12:52 -- Kabogo Ndegwa
Author(s): 
Rodrigues-Duarte L, Vieira de Moraes L, Barboza R, Marinho CR, Franke-Fayard B, Janse CJ, Penha-Goncalves C
Reference: 
Malaria Journal 2012, 11:231 (16 July 2012)

MalariaWorldInfection of pregnant C57BL/6 females with K173, NK65 and ANKADeltapm4 P. berghei parasites provide experimental systems to identify host molecular components involved in PM pathogenesis mechanisms.

Not Open Access | Plasma Concentrations of Parasite Histidine-Rich Protein 2 Distinguish Between Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria in Malawian Children

July 11, 2012 - 14:51 -- Patrick Sampao
Author(s): 
Karl B. Seydel, Lindsay L. Fox, Simon J. Glover, Mathew J. Reeves, Paul Pensulo, Alice Muiruri, Ashley Mpakiza, Malcolm E. Molyneux and Terrie E. Taylor
Reference: 
J Infect Dis. (2012) 206 (3): 309-318.

MalariaWorldWe investigated the utility of plasma concentrations of parasite histidine-rich protein 2 (pHRP2), a Plasmodium-specific protein, as a predictor of intracerebral parasite sequestration at autopsy and of malaria retinopathy on clinical examination in patients with clinically defined CM.

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Not Open Access | Accurate Diagnosis of Cerebral Malaria: A Role for Parasite Histidine-Rich Protein 2?

July 11, 2012 - 14:37 -- Patrick Sampao
Author(s): 
Chandy C. John
Reference: 
J Infect Dis. (2012) 206 (3): 307-308.

MalariaWorldIn a series of elegant autopsy-based studies, Taylor and colleagues demonstrated that as many as 23% of children who meet this WHO definition of cerebral malaria actually die from other causes and that the presence of malaria retinopathy has a >90% sensitivity and specificity for predicting “true” cerebral malaria, in which parasite sequestration is documented in cerebral capillaries

Erythropoietin treatment alleviates ultrastructural myelin changes induced by murine cerebral malaria

June 29, 2012 - 15:18 -- Patrick Sampao
Author(s): 
Hempel C, Hyttel P, Staalsø T, Nyengaard JR, Kurtzhals JA
Reference: 
Malaria Journal 2012, 11:216 (28 June 2012)

MalariaWorld The study objectives were to assess myelin thickness and ultrastructural morphology in the corpus callosum in murine CM and to adress the effects of EPO treatment in this context.

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Open Access | Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA

March 13, 2012 - 06:44 -- Kabogo Ndegwa
Author(s): 
Kouyuki Hirayasu, Jun Ohashi, Toshio Yabe, et al.
Reference: 
PLoS Pathog 8(3): e1002565

MalariaWorldCerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate.

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