Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria
Reference:
PLoS Pathog 8(10): e1002982
Plasmodium falciparum malaria is responsible for nearly one million annual deaths worldwide.
Medical Condition:
Cerebral Malaria
NOT Open Access | Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria
Reference:
Parasite Immunology, Volume 34, Issue 11, pages 547–550, November 2012
Complement receptors for C3-derived fragments (CR1–4) play critical roles in innate and adaptive immune responses.
Medical Condition:
NOT Open Access | Deletion of carboxypeptidase N delays onset of experimental cerebral malaria
Reference:
Parasite Immunology, Volume 34, Issue 8-9, pages 444–447, August/September 2012
Complement contributes to inflammation during pathogen infections; however, less is known regarding its role during malaria and in the severest form of the disease, cerebral malaria.
Medical Condition:
Not Open Access | Blood group phenotypes A and B are risk factors for cerebral malaria in Odisha, India
Reference:
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, Issue 9, September 2012, Pages 538-543
The results showed high prevalence of blood group B in both mild (n = 110) and severe malaria (cerebral malaria [CM]; n = 130 and non-cerebral severe malaria [NCSM]; n = 103) categories among the non-O group and while type O is significantly associated with protection against CM, patients with type A and B group had increased risk for developing CM.
Country:
Region:
Medical Condition:
Not Open Access | Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase acitivity in the hippocampus of survivor mice
Reference:
Neuroscience Letters, Volume 523, Issue 2, 15 August 2012, Pages 104–107
In the present work, we evaluated BDNF protein levels and AChE activity in the hippocampus and habituation in an animal model of CM using C57BL/6 mice after fifteen days of the induction.
Product:
Medical Condition:
Distinct placental malaria pathology caused by different Plasmodium berghei lines that fail to induce cerebral malaria in the C57Bl/6 mouse
Reference:
Malaria Journal 2012, 11:231 (16 July 2012)
Infection of pregnant C57BL/6 females with K173, NK65 and ANKADeltapm4 P. berghei parasites provide experimental systems to identify host molecular components involved in PM pathogenesis mechanisms.
Medical Condition:
Not Open Access | Plasma Concentrations of Parasite Histidine-Rich Protein 2 Distinguish Between Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria in Malawian Children
Reference:
J Infect Dis. (2012) 206 (3): 309-318.
We investigated the utility of plasma concentrations of parasite histidine-rich protein 2 (pHRP2), a Plasmodium-specific protein, as a predictor of intracerebral parasite sequestration at autopsy and of malaria retinopathy on clinical examination in patients with clinically defined CM.
Person:
Country:
Medical Condition:
Not Open Access | Accurate Diagnosis of Cerebral Malaria: A Role for Parasite Histidine-Rich Protein 2?
Reference:
J Infect Dis. (2012) 206 (3): 307-308.
In a series of elegant autopsy-based studies, Taylor and colleagues demonstrated that as many as 23% of children who meet this WHO definition of cerebral malaria actually die from other causes and that the presence of malaria retinopathy has a >90% sensitivity and specificity for predicting “true” cerebral malaria, in which parasite sequestration is documented in cerebral capillaries
Medical Condition:
Erythropoietin treatment alleviates ultrastructural myelin changes induced by murine cerebral malaria
Reference:
Malaria Journal 2012, 11:216 (28 June 2012)
The study objectives were to assess myelin thickness and ultrastructural morphology in the corpus callosum in murine CM and to adress the effects of EPO treatment in this context.
Company:
Medical Condition:
Medical Treatment:
Open Access | Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA
Reference:
PLoS Pathog 8(3): e1002565
Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate.
Medical Condition:
Pages
