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phosphocholine cytidylyltransferase

PG12, a Phospholipid Analog with Potent Antimalarial Activity, Inhibits Plasmodium falciparum CTP:Phosphocholine Cytidylyltransferase Activity

August 16, 2011 - 11:41 -- Patrick Sampao
Author(s): 
Patricia González-Bulnes, April M. Bobenchik, Yoann Augagneur, Rachel Cerdan, Henri J. Vial, Amadeu Llebaria and Choukri Ben Mamoun
Reference: 
August 19, 2011 The Journal of Biological Chemistry, 286, 28940-28947.

Metabolic analyses showed that one of these compounds, PG12, specifically blocks phosphatidylcholine biosynthesis from both the CDP-choline and SDPM pathways via inhibition of PfCCT. In vitro studies using recombinant PfCCT showed a dose-dependent inhibition of the enzyme by PG12.

Medical Treatment: 
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