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Drug Resistance

Open Access | Methodology: Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction

May 24, 2010 - 13:02 -- Kabogo Ndegwa
Author(s): 
Gan L, Loh J
Reference: 
Malaria Journal 2010, 9:134 (21 May 2010)

PCR-HRM is an inexpensive option for the determination of drug resistance profile in P. falciparum and will see increasing use as an alternative to sequencing and 5'nuclease PCR assays in reference laboratories or once PCR systems that are able to conduct HRM become commonplace.

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High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon

March 10, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Marielle Karine Bouyou-Akotet, Denise Patricia Mawili-Mboumba, Tanguy de Dieu Tchantchou, and Maryvonne Kombila
Reference: 
J. Antimicrob. Chemother. 2010 65: 438-441

These findings underline the need for a regular assessment of the relationship between the presence of resistant isolates and in vitro/in vivo IPTp/SP efficacy, and evaluation of an alternative drug.

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Open Access | Review: In vitro selection of Plasmodium falciparum drug-resistant parasite lines

March 10, 2010 - 13:43 -- Ingeborg van Schayk
Author(s): 
Alexis Nzila and Leah Mwai
Reference: 
J. Antimicrob. Chemother. 2010 65: 390-398; doi:10.1093/jac/dkp449

In this review, we discuss the key parameters that impact on the efficiency of the in vitro selection of resistance, and propose strategies to improve and streamline this process.

Open Access | Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates

March 9, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Sabelo V Dlamini, Khalid Beshir, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:68 (3 March 2010)

Anti-malarial policy changes in neighbouring countries may have had an impact on the prevalence of molecular markers of anti-malarial resistance in Swaziland, and it is hoped that this new information will add to understanding of the regional anti-malarial resistance map.

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Short communication: Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso

March 5, 2010 - 11:00 -- Kabogo Ndegwa
Author(s): 
Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 63-66

The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area.

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Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugates

December 22, 2009 - 12:59 -- Patrick Sampao
Author(s): 
Sunny Manohar, Shabana I. Khan, Diwan S. Rawat
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 1, 1 January 2010, Pages 322-325

A series of 4-aminoquinoline–triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum.

Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance

November 25, 2009 - 16:38 -- Ingeborg van Schayk
Tags: 
Author(s): 
Nicholas J White, Wirichada Pongtavornpinyo, Richard J Maude, Sompob Saralamba, Ricardo Aguas, Kasia Stepniewska, Sue J Lee, Arjen M Dondorp, Lisa J White, Nicholas PJ Day
Reference: 
Malaria Journal 2009, 8:253 (11 November 2009)

The probability of de-novo resistant malaria parasites surviving and transmitting depends on the relationship between their degree of resistance and the blood concentration profiles of the anti-malarial drug to which they are exposed. The conditions required for the in-vivo selection of de-novo emergent resistant malaria parasites were examined and relative probabilities assessed.

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Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone

November 13, 2009 - 10:11 -- Ingeborg van Schayk
Tags: 
Author(s): 
Mirko Altenkämper et al.
Reference: 
Bioorganic & Medicinal Chemistry Volume 17, Issue 22, 15 November 2009, Pages 7690-7697

Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity.

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Inaugural Article: Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

November 11, 2009 - 10:16 -- Ingeborg van Schayk
Author(s): 
Juliana Martha Sá, Olivia Twu, Karen Hayton, Sahily Reyes, Michael P. Fay, Pascal Ringwald, and Thomas E. Wellems
Reference: 
PNAS November 10, 2009 vol. 106 no. 45 18883-18889

Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America.

 

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