The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10084 malaria professionals are enjoying the free benefits of MalariaWorld today

Drug Resistance

Open Access | Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana

April 19, 2012 - 07:28 -- Kabogo Ndegwa
Author(s): 
Sara N. Mitchell, Bradley J. Stevenson, Pie Müller, Craig S. Wilding, Alexander Egyir-Yawson, Stuart G. Field, Janet Hemingway, Mark J. I. Paine, Hilary Ranson, and Martin James Donnelly
Reference: 
PNAS April 17, 2012 vol. 109 no. 16 6147-6152

MalariaWorldIn the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa.

Country: 

Open Access | Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya

March 29, 2012 - 08:21 -- Kabogo Ndegwa
Author(s): 
McCollum AM, Schneider KA, Griffing SM, Zhou Z, Kariuki S, Ter-Kuile F, Shi Y, Slutsker L, Lal AA, Udhayakumar V, Escalante AA
Reference: 
Malaria Journal 2012, 11:77 (22 March 2012)

MalariaWorldThe complexity of these observations emphasizes the importance of population-based studies to evaluate the effects of strong drug selection on Plasmodium falciparum populations.

Country: 
Medical Condition: 

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

March 22, 2012 - 06:30 -- Kabogo Ndegwa
Author(s): 
Daniel E. Goldberg, Robert F. Siliciano, William R. Jacobs
Reference: 
Cell, Volume 148, Issue 6, 16 March 2012, Pages 1271–1283

MalariaWorldAlthough caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance.

Medical Condition: 

Open Access | Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes

November 17, 2011 - 07:50 -- Kabogo Ndegwa
Author(s): 
Sungano Mharakurwa, Taida Kumwenda, Mtawa A. P. Mkulama, Mulenga Musapa, Sandra Chishimba, Clive J. Shiff, David J. Sullivan, Philip E. Thuma, Kun Liu, and Peter Agre
Reference: 
PNAS November 15, 2011 vol. 108 no. 46 18796-18801

MalariaWorldSurveillance for drug-resistant parasites in human blood is a major effort in malaria control.

Malaria drug resistance: new observations and developments.

October 27, 2011 - 13:35 -- Patrick Sampao
Author(s): 
Sá JM, Chong JL, Wellems TE
Reference: 
Essays Biochem. 2011 Oct 24;51:137-60.

MalariaWorldWe review some contributions that early efficacy studies of antimalarial treatment brought to clinical pharmacology, including convincing documentation of atebrine-resistant malaria in the 1940s, prior to the launching of what soon became first-choice antimalarials, chloroquine and amodiaquine.

Continent: 
Medical Condition: 
Medical Treatment: 

Open Access | A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes

September 29, 2011 - 08:03 -- Kabogo Ndegwa
Author(s): 
Celine Barnadas, David Kent, Lincoln Timinao, Jonah Iga, Laurie R Gray, Peter Siba, Ivo Mueller, Peter J Thomas, Peter A Zimmerman
Reference: 
Malaria Journal 2011, 10:282 (24 September 2011)

MalariaWorldThe LDR-FMA described here allows a discriminant genotyping of resistance alleles in the pvdhfr, pvdhps, and pvmdr1 genes and can be used in large-scale surveillance studies.

Drug resistance maps to guide intermittent preventive treatment of malaria in African infants

September 28, 2011 - 06:58 -- Kabogo Ndegwa
Author(s): 
Inbarani Naidoo, Cally Roper
Reference: 
Parasitology, Volume 138, Special Issue 12 - Symposia of the British Society for Parasitology Volume 47, October 2011, pp 1469 – 1479

Intermittent preventive treatment of infants (IPTi) with sulphadoxine pyrimethamine (SP) is recommended as an additional malaria control intervention in high transmission areas of sub-Saharan Africa, provided its protective efficacy is not compromised by SP resistance.

Person: 
Continent: 
Medical Condition: 
Medical Treatment: 

Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

September 21, 2011 - 06:27 -- Kabogo Ndegwa
Author(s): 
Sofia Borges, Pedro Cravo, Alison Creasey, Richard Fawcett, Katarzyna Modrzynska, Louise Rodrigues, Axel Martinelli, and Paul Hunt
Reference: 
Antimicrobial Agents and Chemotherapy, October 2011,p. 4858-4865, Vol. 55, No. 10

Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs).

Medical Condition: 
Medical Treatment: 

Open Access | Rapid whole genome optical mapping of Plasmodium falciparum

August 31, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
Riley MC, Kirkup BC, Johnson JD, Lesho EP, Ockenhouse CF
Reference: 
Malaria Journal 2011, 10:252 (26 August 2011)

This technique for optical mapping of multiple malaria genomes allows for whole genome comparison of multiple strains and can assist in identifying genetic variation and sequence contig assembly.

Open Access | Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites

August 30, 2011 - 11:26 -- Kabogo Ndegwa
Author(s): 
Diakite M, Achidi EA, Ranford-Cartwright LC, et al.
Reference: 
Malaria Journal 2011, 10:250 (25 August 2011)

The study showed significant association of three loci in the human genome with the ability of patients to clear drug-resistant P. falciparum in samples taken from five countries distributed across sub-Saharan Africa.

Continent: 

Pages

Subscribe to RSS - Drug Resistance