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falcipains

Open Access | Review: Structure-Function of Falcipains: Malarial Cysteine Proteases

February 21, 2012 - 13:47 -- Patrick Sampao
Author(s): 
Kailash C. Pandey and Rajnikant Dixit
Reference: 
Journal of Tropical Medicine, Volume 2012 (2012)

MalariaWorldStructural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain.

Medical Condition: 

Falcipains and other cysteine proteases of malaria parasites.

June 14, 2011 - 13:33 -- Patrick Sampao
Author(s): 
Rosenthal PJ
Reference: 
Adv Exp Med Biol. 2011;712:30-48.

Gene disruption studies suggested that SERA-5 and SERA-6 are essential. activation of SERA-5 by a serine protease seems to be required for merozoite egress from the erythrocyte. New drugs for malaria are greatly needed and cysteine proteases represent potential drug targets.

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