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PAK-MEK

Open Access | Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

June 8, 2011 - 15:06 -- Patrick Sampao
Author(s): 
Audrey Sicard, Jean-Philippe Semblat, Christian Doerig, et al
Reference: 
Cellular Microbiology, Volume 13, Issue 6, pages 836–845, June 2011

Here, we report that a protein kinase-mediated signalling pathway involving host RBC PAK1 and MEK1, which do not have orthologues in the Plasmodium kinome, is selectively stimulated in Plasmodium falciparum-infected (versus uninfected) RBCs, as determined by the use of phospho-specific antibodies directed against the activated forms of these enzymes.

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