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Positive Selection of Plasmodium falciparum Parasites With Multiple var2csa-Type PfEMP1 Genes During the Course of Infection in Pregnant Women

May 19, 2011 - 09:35 -- Patrick Sampao
Adam F. Sander, Ali Salanti, Thomas Lavstsen, Morten A. Nielsen, Thor G. Theander, Rose G. F. Leke, Yeung Y. Lo, Naveen Bobbili, David E. Arnot and Diane W. Taylor
J Infect Dis. (2011) 203 (11): 1679-1685.

The data suggest that multiplicity of var2csa-type genes enables P. falciparum parasites to persist for a longer period of time during placental infections, probably because of their greater capacity for antigenic variation and evasion of variant-specific immune responses.

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