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var2csa-Type

Positive Selection of Plasmodium falciparum Parasites With Multiple var2csa-Type PfEMP1 Genes During the Course of Infection in Pregnant Women

May 19, 2011 - 09:35 -- Patrick Sampao
Author(s): 
Adam F. Sander, Ali Salanti, Thomas Lavstsen, Morten A. Nielsen, Thor G. Theander, Rose G. F. Leke, Yeung Y. Lo, Naveen Bobbili, David E. Arnot and Diane W. Taylor
Reference: 
J Infect Dis. (2011) 203 (11): 1679-1685.

The data suggest that multiplicity of var2csa-type genes enables P. falciparum parasites to persist for a longer period of time during placental infections, probably because of their greater capacity for antigenic variation and evasion of variant-specific immune responses.

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