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liver stage

Review: A toolbox to study liver stage malaria

November 21, 2011 - 12:41 -- Patrick Sampao
Miguel Prudêncio, Maria M. Mota, António M. Mendes
Trends in Parasitology, Volume 27, Issue 12, December 2011, Pages 565-574

MalariaWorldHere, we review appropriate infection models and infection assessment tools, and provide a comprehensive description of recent advances in experimental strategies to investigate the liver stage of malaria.

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

July 21, 2010 - 07:09 -- Patrick Sampao
James F., Michele D., et al.
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 5135-5144

Although the optimal antigen dose of LSA-NRC may not have been selected for the challenge portion of the protocol, further vaccine development based upon LSA-1 should not be excluded and should include alternative vaccine platforms able to elicit additional effector mechanisms such as CD8+ T cells.

Medical Treatment: 

Open Access | Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

May 10, 2010 - 08:52 -- Kabogo Ndegwa
Ian A. Cockburn, Yun-Chi Chen, Michael G. Overstreet, Jason R. Lees, Nico van Rooijen, Donna L. Farber, Fidel Zavala
PLoS Pathog 6(5): e1000877

Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach are unknown. Here we show that the complete development of protective CD8+ T cell responses requires prolonged antigen presentation.

Microbiology and virology: Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility

March 11, 2010 - 13:21 -- Patrick Sampao
Peter Liehl, Ana Rita França, Miguel Prudêncio, Eicke Latz, Anna Zaidman-Rémy, Maria M. Mota
Cellular Microbiology,Volume 12, Issue 4, April 2010, Pages: 506-515

Altogether, PS-ODNs might represent a new class of prophylactic anti-malaria agents, which hamper hepatocyte entry by Plasmodium sporozoites.

Open Access | Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging

December 12, 2009 - 12:40 -- Ingeborg van Schayk
Ploemen IHJ, Prudêncio M, Douradinha BG, Ramesar J, Fonager J, et al.
PLoS ONE 4(11): e7881

Here we report the use of a transgenic P. berghei parasite, PbGFP-Luccon, expressing the bioluminescent reporter protein luciferase to visualize and quantify parasite development in liver cells both in culture and in live mice using real-time luminescence imaging.

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