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Falciparum

Two Case Reports of Successful Therapeutic Erythrocytapheresis as an Adjunctive Therapy in Severe Falciparum Malaria

March 31, 2010 - 12:07 -- Patrick Sampao
Author(s): 
Hae-Sun Chung, Kyong Ran Peck, Dae-Won Kim
Reference: 
Therapeutic Apheresis and Dialysis, Volume 14, Issue 2, April 2010, Pages: 230-233

For many years, erythrocytapheresis has been used for the rapid removal of parasites in patients with severe and complicated malaria. Here, we report two cases of severe Plasmodium falciparum infection treated by erythrocytapheresis in addition to antimalarial chemotherapy.

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Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand

March 31, 2010 - 11:26 -- Patrick Sampao
Author(s): 
Somchai Jongwutiwes, Chaturong Putaporntip, Austin L. Hughes
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3112-3117

These results suggest a two-pronged strategy for malaria eradication: (1) strenuous non-vaccine control measures that will cause a severe population bottleneck in the parasite; and (2) a subsequent local vaccine focused on one or a few locally occurring alleles at antigen-encoding loci.

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Predictive factors of severe disease secondary to falciparum malaria among travelers

March 25, 2010 - 13:39 -- Ingeborg van Schayk
Author(s): 
G. Saliba, W. Kamouh, A. Fontanet, J. Le Bras
Reference: 
Pathologie Biologie, In Press, Corrected Proof, Available online 19 March 2010

This study points out two particularly interesting results: severe malaria is significantly associated with the infection by a chloroquine resistant P. falciparum phenotype and with the parasite's acquisition in the south-eastern asian region.

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Open Access | Serologic Markers for Detecting Malaria in Areas of Low Endemicity, Somalia, 2008

March 24, 2010 - 10:41 -- Ingeborg van Schayk
Author(s): 
T. Bousema et al.
Reference: 
EID, Volume 16, Number 3–March 2010

Areas in which malaria is not highly endemic are suitable for malaria elimination, but assessing transmission is difficult because of lack of sensitivity of commonly used methods. We evaluated serologic markers for detecting variation in malaria exposure in Somalia.

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Open Access | Comparative detection of Plasmodium vivax and Plasmodium falciparum DNA in saliva and urine samples from symptomatic malaria patients in a low endemic area

March 14, 2010 - 10:17 -- Ingeborg van Schayk
Author(s): 
Pattakorn Buppan, Chaturong Putaporntip, Urassaya Pattanawong, Sunee Seethamchai, Somchai Jongwutiwes
Reference: 
Malaria Journal 2010, 9:72 (9 March 2010)

Saliva and urine samples could be alternative noninvasive sources of DNA for molecular detection of both P. falciparum and P. vivax. Further improvement of the detection method will offer an opportunity to use these samples for diagnosis of malaria.

An autologous falciparum vaccine using the erythrocyte’s band 3 molecule

February 13, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
James Randall Kennedy
Reference: 
Medical Hypotheses, Volume 74, Issue 3, March 2010, Pages 503-504

A conjugate vaccine using these peptides in early infancy may allow those infants to survive a falciparum infection and develop comprehensive natural immunity to the local endemic parasite.

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Henoch-Schönlein Purpura Triggered by Falciparum Cerebral Malaria

February 4, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Rajoo Thapa, Debkrishna Mallick, Biswajit Biswas, Apurba Ghosh, Subroto Chakrabartty, and Sandipan Dhar
Reference: 
Clinical Pediatrics. published 28 January 2010

The present report details the case of a young Indian boy with falciparum cerebral malaria, whose clinical course was complicated by the development of a palpable purpuric rash, severe abdominal pain, and grossly bloody stools, leading to the diagnosis of HSP, in accordance with the American College of Rheumatology criteria. 

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Coagulation Status and Platelet Functions in Children with Severe Falciparum Malaria and their Correlation of Outcome

December 21, 2009 - 12:08 -- Ingeborg van Schayk
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Author(s): 
Rajniti Prasad, B. K. Das, Rahul Pengoria, Om P. Mishra, Jyoti Shukla, and Tej B. Singh
Reference: 
J Trop Pediatr 2009 55: 374-378; doi:10.1093/tropej/fmp028

This study was undertaken to observe the changes in coagulation and platelet profile, and findings were correlated with their outcome.

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Therapeutic Efficacy and Effects of Artesunate-Mefloquine and Mefloquine Alone on Malaria-Associated Anemia in Children with Uncomplicated Plasmodium falciparum Malaria in Southwest Nigeria

December 18, 2009 - 16:19 -- Ingeborg van Schayk
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Author(s): 
Akintunde Sowunmi, Grace O. Gbotosho, Christian Happi, Titilope Okuboyejo, Onikepe Folarin, Sulayman Balogun, AND Obaro Michael
Reference: 
Am J Trop Med Hyg 2009;81 979-986

Both regimens were well tolerated. AMQ clears parasitemia and reduces gametocyte carriage more rapidly and causes lesser fall in hematocrit than MQ, but both regimens are effective treatment of uncomplicated P. falciparum malaria in Nigerian children.

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Test characteristics of the SD FK80 Plasmodium falciparum/Plasmodium vivax malaria rapid diagnostic test in a non-endemic setting

November 26, 2009 - 12:29 -- Ingeborg van Schayk
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Author(s): 
Philippe Gillet, David PJ van Dijk, Emmanuel Bottieau, Lieselotte Cnops, Marjan Van Esbroeck, Jan Jacobs
Reference: 
Malaria Journal 2009, 8:262 (22 November 2009)

The SD FK80 P.f/P.v Malaria Antigen Rapid Test (Standard Diagnostics, Korea) (FK80) is a three-band malaria rapid diagnostic test detecting Plasmodium falciparum histidine-rich protein-2 (HRP-2) and Plasmodium vivax-specific lactate dehydrogenase (Pv-pLDH). The present study assessed its performance in a non-endemic setting.

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