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Falciparum

High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India

April 16, 2010 - 12:50 -- Patrick Sampao
Author(s): 
Manoj K. Das, Vanshika Lumb, Pooja Mittra, Shiv S. Singh, Aditya P. Dash and Yagya D. Sharma
Reference: 
Journal of Antimicrobial Chemotherapy

A WHO protocol with a 28 day follow-up schedule was used for chloroquine efficacy studies. Finger-prick blood from P. falciparum malaria patients was used for sequencing the genes encoding PfCRT (exon 2), dihydrofolate reductase (PfDHFR) and dihydropteroate synthetase (PfDHPS).

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Epidemiology and control of frontier malaria in Brazil: lessons from community-based studies in rural Amazonia

April 16, 2010 - 09:58 -- Patrick Sampao
Author(s): 
Natal S. S., M. da Silva-N., et al.
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 5, May 2010, Pages 343-350

We analysed the incidence of slide-confirmed symptomatic infections diagnosed between 2001 and 2006 in a cohort of 531 individuals (2281.53 person-years of follow-up) and parasite prevalence data derived from four cross-sectional surveys.

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Open Access | Epitope mapping of PfCP-2.9, an asexual blood-stage vaccine candidate of Plasmodium falciparum

April 15, 2010 - 11:50 -- Kabogo Ndegwa
Author(s): 
Li C, Wang R, Wu Y, Zhang D, He Z, Pan W
Reference: 
Malaria Journal 2010, 9:94 (12 April 2010)

This study provided valuable information on epitopes of PfCP-2.9 vaccine candidate through generation of a panel of mAbs and a series of PfCP-2.9 mutants. The information may prove to be useful for designing more effective malaria vaccines against blood-stage parasites.

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Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum

April 15, 2010 - 08:27 -- Patrick Sampao
Author(s): 
R. Jain, R. Jordanova, I. B. Müller, C. Wrenger and M. R. Groves
Reference: 
Structural Biology and Crystallization Communications, Volume 66, Part 4 (April 2010)

The successful crystallization of PfAspAT, the collection of a 2.8 Å diffraction data set and initial attempts to solve the structure using molecular replacement are reported.

Clinical Microbiology: Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) versus artemether-lumefantrine (Coartem®) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast

April 13, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
Babacar Faye, André Touré Offianan, Jean Louis Ndiaye, Roger Clement Tine, Walatchin Touré, Kali Djoman, Khadime Sylla, Paulette Suzanne Ndiaye, Louis Penali, Oumar Gaye
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 5, May 2010, Pages: 608-613

This study demonstrates the efficacy and tolerability of AS + AQ for uncomplicated Plasmodium falciparum malaria treatment in African patients over the age of 7 years.

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Transmission and Cross-Mating of High-Level Resistance Plasmodium falciparum Dihydrofolate Reductase Haplotypes in The Gambia

April 13, 2010 - 09:05 -- Patrick Sampao
Author(s): 
Amani Kheir, Davis Nwakanma, Aisha Al-Gazali, Yagut Akbarova, Salma Al-Saai, Göte Swedberg, AND Hamza A. Babiker
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 535-541

Similarities were seen between pfg377 and MSP-1 alleles in children and mosquitoes and evidence of cross-mating between different parasite genotypes was seen in some infected mosquitoes, reflecting high transmission success of existing clones.

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Open Access | Hemolysis Is Associated with Low Reticulocyte Production Index and Predicts Blood Transfusion in Severe Malarial Anemia

April 8, 2010 - 13:04 -- Kabogo Ndegwa
Author(s): 
Rolf Fendel, Christian Brandts, Annika Rudat, Andrea Kreidenweiss, Claudia Steur, Iris Appelmann, Bettina Ruehe, Paul Schröder, Wolfgang E. Berdel, Peter G. Kremsner, Benjamin Mordmüller
Reference: 
PLoS ONE 5(4): e10038.

In Gabon, Central Africa, one out of four inpatients have severe malarial anemia (SMA), a life-threatening complication if left untreated. Our results show the multifactorial pathophysiology of SMA, whereby EVH and IVH play a particularly important role. 

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High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India

April 8, 2010 - 12:39 -- Kabogo Ndegwa
Author(s): 
MK Das, V Lumb, P Mittra, SS Singh, AP Dash, YD Sharma
Reference: 
Journal of Antimicrobial Chemotherapy April 2, 2010

There is a predominance of chloroquine- and antifolate-resistant P. falciparum malaria in Car Nicobar, requiring an alternative antimalarial drug treatment policy, such as implementation of artesunate combination therapy (ACT), for this island.

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Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme

April 8, 2010 - 08:24 -- Kabogo Ndegwa
Author(s): 
F Omodeo-Sale, L Cortelezzi, Z Vommaro, D Scaccabarozzi, A Dondorp
Reference: 
Am J Physiol Cell Physiol (March 31, 2010)

Severe falciparum malaria is associated with hypoargininemia, which contributes to impaired systemic and pulmonary NO production and endothelial dysfunction.

Open Access | Research: Active case detection, treatment of falciparum malaria with combined chloroquine and sulphadoxine/pyrimethamine and vivax malaria with chloroquine and molecular markers of anti-malarial resistance in the Republic of Vanuatu

April 7, 2010 - 12:38 -- Kabogo Ndegwa
Author(s): 
Kinzer MH, Chand K, Basri H, Lederman ER, Susanti AI, Elyazar I, Taleo G, Rogers WO, Bangs MJ, Maguire JD
Reference: 
Malaria Journal 2010, 9:89 (6 April 2010)

The only in vivo malaria drug efficacy trial thus far published from the Republic of Vanuatu showed chloroquine/sulphadoxine-pyrimethamine combination therapy for P. falciparum and chloroquine alone for P. vivax to be highly efficacious.

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