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Falciparum

Open Access | A Plasmodium falciparum Transcriptional Cyclin-Dependent Kinase-Related Kinase with a Crucial Role in Parasite Proliferation Associates with Histone Deacetylase Activity

June 4, 2010 - 08:08 -- Patrick Sampao
Author(s): 
Jean H., Lawrence A., et al.
Reference: 
Eukaryotic Cell, June 2010, p. 952-959, Vol. 9, No. 6

We show that recombinant Pfcrk-3 associates with histone H1 kinase activity in parasite extracts and that this association is detectable even if the catalytic domain of Pfcrk-3 is rendered inactive by site-directed mutagenesis, indicating that Pfcrk-3 is part of a complex that includes other protein kinases.

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Open Access | Baseline spatial distribution of malaria prior to an elimination programme in Vanuatu

June 3, 2010 - 08:08 -- Kabogo Ndegwa
Author(s): 
Reid H, Vallely A, Taleo G, Tatem AJ, Kelly G, Riley I, Harris I, Henri I, Iamaher S, Clements AC
Reference: 
Malaria Journal 2010, 9:150 (2 June 2010)

Malaria in Tanna Island, Vanuatu, has a focal and predominantly coastal distribution. As Vanuatu refines its elimination strategy, malaria risk maps represent an invaluable resource in the strategic planning of all levels of malaria interventions for the island.

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Review: Exploiting the therapeutic potential of Plasmodium falciparum solute transporters

May 31, 2010 - 14:25 -- Patrick Sampao
Author(s): 
Henry M. Staines, Elvira T. Derbyshire, Ksenija Slavic, Amanda Tattersall, Henri Vial, Sanjeev Krishna
Reference: 
Trends in Parasitology, Volume 26, Issue 6, June 2010, Pages 284-296

Presented here is an overview of our current understanding of the transport processes used by Plasmodium parasites, with an emphasis on their therapeutic potential.

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Cellular Immunology and Immune Regulation: Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

May 31, 2010 - 12:22 -- Kabogo Ndegwa
Author(s): 
Amir Horowitz, Kirsty C. Newman, J. Henry Evans, Daniel S. Korbel, Daniel M. Davis, and Eleanor M. Riley
Reference: 
J. Immunol., Jun 2010; 184: 6043 – 6052

Rapid cell-mediated immune responses, characterized by production of proinflammatory cytokines, such as IFN-{gamma}, can inhibit intraerythrocytic replication of malaria parasites and thereby prevent onset of clinical malaria.

Open Access | Hyponatraemia in imported malaria is common and associated with disease severity

May 27, 2010 - 11:20 -- Patrick Sampao
Author(s): 
van Wolfswinkel ME, Hesselink DA, Zietse R, Hoorn EJ, van Genderen PJ
Reference: 
Malaria Journal 2010, 9:140 (25 May 2010)

The aim of this retrospective cohort study was to determine the prevalence of hyponatraemia and its association with malaria severity in a large cohort of patients with imported malaria caused by various Plasmodium species.

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Open Access | Plasmodium falciparum proteome changes in response to doxycycline treatment

May 27, 2010 - 07:36 -- Patrick Sampao
Author(s): 
Briolant S, Almeras L, Belghazi M, Boucomont-Chapeaublanc E, Wurtz N, Fontaine A, Granjeaud S, Fusai T, Rogier C, Pradines B
Reference: 
Malaria Journal 2010, 9:141 (25 May 2010)

A proteomic approach was used to analyse protein expression changes in the schizont stage of the malarial parasite P. falciparum following doxycycline treatment.

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Open Access | Genetic structure of Plasmodium vivax and Plasmodium falciparum in the Bannu district of Pakistan

April 27, 2010 - 14:24 -- Kabogo Ndegwa
Author(s): 
Khatoon L, Baliraine FN, Bonizzoni M, Malik SA, Yan G
Reference: 
Malaria Journal 2010, 9:112 (23 April 2010)

These results indicate that both P. vivax and P. falciparum populations in Pakistan are highly diverse.

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Options for improving malaria treatment: Introduction

April 21, 2010 - 08:22 -- Patrick Sampao
Author(s): 
Andrew D. Oxmana, Ambachew M. Yohannesa and John-Arne Røttingena
Reference: 
International Journal of Technology Assessment in Health Care (2010), 26:228-228

This Theme Section of IJTAHC presents summaries of six policy briefs that address scaling up of artemisinin-based combination therapies (ACTs) in the treatment of uncomplicated falciparum malaria in Africa.

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Mechanisms of Resistance: Selection of Known Plasmodium falciparum Resistance-Mediating Polymorphisms by Artemether-Lumefantrine and Amodiaquine- Sulfadoxine-Pyrimethamine but Not Dihydroartemisinin- Piperaquine in Burkina Faso

April 20, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Anyirékun Fabrice Somé, Yves Y. Séré, Christian Dokomajilar, Issaka Zongo, Noël Rouamba, Bryan Greenhouse, Jean-Bosco Ouédraogo, and Philip J. Rosenthal
Reference: 
Antimicrobial Agents and Chemotherapy, May 2010, p. 1949-1954, Vol. 54, No. 5

Artemether-lumefantrine (AL), dihydroartemisinin-piperaquine (DP), and amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) offer excellent antimalarial efficacy but may select for parasite polymorphisms that decrease drug sensitivity. We evaluated the selection of known polymorphisms in genes encoding putative transporters (pfcrt and pfmdr1) and SP targets (pfdhfr and pfdhps) in parasites that caused new infections within 42 days of therapy for uncomplicated falciparum malaria in Burkina Faso.

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