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Falciparum

Short Communication: Plasmodium vivax in the Democratic Republic of East Timor: Parasite prevalence and antifolate resistance-associated mutations

June 9, 2010 - 08:22 -- Kabogo Ndegwa
Author(s): 
Afonso de Almeida, Virgílio E. do Rosário, Gisela Henriques, Ana Paula Arez, Pedro Cravo
Reference: 
Acta Tropica, Volume 115, Issue 3, September 2010, Pages 288-292

In the Democratic Republic of East Timor, Plasmodium falciparum and Plasmodium vivax malaria coexist, but limited information is available about the latter species. Consequently, the prevalence of P. vivax and of its corresponding antifolate resistance-associated mutations in the pvdhfr and pvdhps genes was assessed here.

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Malaria

June 9, 2010 - 08:14 -- Kabogo Ndegwa
Author(s): 
Lynne S. Garcia MS, MT, CLS
Reference: 
Clinics in Laboratory Medicine, Volume 30, Issue 1, March 2010, Pages 93-129

Malaria has had a greater impact on world history than any other infectious disease. More than 300 to 500 million individuals worldwide are infected with Plasmodium spp, and 1.5 to 2.7 million people a year, most of whom are children, die from the infection.

Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from cameroon with uncomplicated falciparum malaria

June 9, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
F Tietche, D Chelo, NK Mina Ntoto, FM Djoukoue, C Hatz, S Frey, A Frentzel, S Trapp, R Zielonka, EA Mueller
Reference: 
Am. J. Trop. Med. Hyg., 82(6), 2010, pp. 1034-1040

A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of neuropsychiatric adverse events (AEs). In total, 220 subjects, weighing between 10 and 20 kg, were enrolled; 213 qualified for analysis.

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Manadoperoxides A-D from the Indonesian Sponge Plakortis cfr. simplex. Further Insights on the Structure-Activity Relationships of Simple 1,2-Dioxane Antimalarials

June 9, 2010 - 08:01 -- Kabogo Ndegwa
Author(s): 
C Fattorusso, M Persico, B Calcinai, C Cerrano, S Parapini, D Taramelli, E Novellino, A Romano, F Scala, E Fattorusso, O Taglialatela-Scafati
Reference: 
J. Nat. Prod. June 3, 2010

The new endoperoxyketal polyketides manadoperoxides A−D (2−5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic data and semisynthetic transformations.

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Open Access | Field evaluation of a rapid diagnostic test (ParascreenTM) for malaria diagnosis in the Peruvian Amazon

June 8, 2010 - 09:54 -- Kabogo Ndegwa
Author(s): 
Bendezu J, Rosas A, Grande T, Rodriguez H, Llanos-Cuentas A, Escobedo J, Gamboa D
Reference: 
Malaria Journal 2010, 9:154 (7 June 2010)

The study results indicate that ParascreenTM is not a valid and acceptable test for malaria diagnosis under the field conditions found in the Peruvian Amazon.

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Open Access | Methodology: Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

June 7, 2010 - 12:05 -- Patrick Sampao
Author(s): 
Wilson DW, Crabb BS, Beeson JG
Reference: 
Malaria Journal 2010, 9:152 (3 June 2010)

Flow cytometry based assays using GFP-fluorescent parasites proved sensitive and highly reproducible for quantifying the growth-inhibitory activity of antibodies and anti-malarials, with superior reproducibility to light microscopy, and are suitable for high-throughput applications.

Open Access | Use of HRP-2-based rapid diagnostic test for Plasmodium falciparum malaria: assessing accuracy and cost-effectiveness in the villages of Dielmo and Ndiop, Senegal

June 7, 2010 - 11:51 -- Kabogo Ndegwa
Author(s): 
Ly A, Tall A, Perry R, Baril L, Badiane A, Faye J, Rogier C, Toure A, Sokhna C, Trape J, Michel R
Reference: 
Malaria Journal 2010, 9:153 (4 June 2010)

A rational use of ACT requires laboratory testing of all patients presenting with presumed malaria. Use of RDTs inevitably has incremental costs, but the strategy associating RDT use for all clinically suspected malaria and prescribing ACT only to patients tested positive is cost-effective in areas where microscopy is unavailable.

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Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 7, 2010 - 11:47 -- Kabogo Ndegwa
Author(s): 
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
Reference: 
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Red Cells, Iron, and Erythropoiesis: Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites

June 7, 2010 - 09:06 -- Patrick Sampao
Author(s): 
Michelle J. Boyle, Jack S. Richards, Paul R. Gilson, Wengang Chai, and James G. Beeson
Reference: 
Blood, Jun 2010; 115: 4559 - 4568.

All P falciparum isolates tested, and parasites using different invasion pathways were inhibited to comparable levels. Furthermore, it was not possible to select for heparin-resistant parasites. Heparin-like molecules occur naturally on the surface of human erythrocytes, where they may act as receptors for binding of merozoite surface proteins.

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Red Cells, Iron, and Erythropoiesis: Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth

June 7, 2010 - 08:47 -- Patrick Sampao
Author(s): 
Benno K., Christina K., et al.
Reference: 
Blood, Jun 2010; 115: 4551 - 4558.

Infants with HbAS were protected from uncomplicated malaria (P < .005) and anemia (P < .001), had lower age-adjusted parasite densities (P < .001), and higher age-adjusted hemoglobin levels compared with children with the HbAA genotype (P = .004).

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