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Falciparum

Open Access | Cognitive Dysfunction Is Sustained after Rescue Therapy in Experimental Cerebral Malaria, and Is Reduced by Additive Antioxidant Therapy

June 29, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
Patricia A. Reis, Clarissa M. Comim, Hugo C. Castro-Faria-Neto, .et al
Reference: 
PLoS Pathog 6(6): e1000963

Neurological impairments are frequently detected in children surviving cerebral malaria (CM), the most severe neurological complication of infection with Plasmodium falciparum.

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Report: New Stages in the Program of Malaria Parasite Egress Imaged in Normal and Sickle Erythrocytes

June 24, 2010 - 08:28 -- Kabogo Ndegwa
Author(s): 
Svetlana Glushakova, Glen Humphrey, Evgenia Leikina, Amanda Balaban, Jeffrey Miller, Joshua Zimmerberg
Reference: 
Current Biology, Volume 20, Issue 12, 22 June 2010, Pages 1117-1121

The apicomplexan parasite Plasmodium falciparum causes malignant malaria. The mechanism of parasite egress from infected erythrocytes that disseminate parasites in the host at the end of each asexual cycle is unknown [1].

Open Access | Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

June 22, 2010 - 10:36 -- Kabogo Ndegwa
Author(s): 
Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, Niangaly A, Duan J, Ellis RD, Miller LH, Su X, Plowe CV, Doumbo OK
Reference: 
Malaria Journal 2010, 9:175 (21 June 2010)

This Phase 2 trial of a bivalent AMA1 malaria vaccine found no evidence of vaccine selection or strain-specific efficacy, suggesting that the extreme genetic diversity of AMA1 did not account for failure of the vaccine to provide protection.

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Open Access | Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum

June 22, 2010 - 07:16 -- Kabogo Ndegwa
Author(s): 
Carmenza Spadafora, Gordon A. Awandare, Karen M. Kopydlowski, Jozsef Czege, J. Kathleen Moch, Robert W. Finberg, George C. Tsokos, José A. Stoute
Reference: 
PLoS Pathog 6(6): e1000968

Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood. P. falciparum depends heavily on sialic acid present on glycophorins to invade erythrocytes.

Open Access | Model variations in predicting incidence of Plasmodium falciparum malaria using 1998-2007 morbidity and meteorological data from south Ethiopia

June 18, 2010 - 12:30 -- Patrick Sampao
Author(s): 
Loha E, Lindtjorn B
Reference: 
Malaria Journal 2010, 9:166 (16 June 2010)

This study describes P. falciparum malaria incidence models linked with meteorological data. Variability in the models was principally attributed to regional differences, and a single model was not found that fits all locations.

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Open Access | New synchronization method for Plasmodium falciparum

June 18, 2010 - 10:10 -- Patrick Sampao
Author(s): 
Ranford-Cartwright LC, Sinha A, Humphreys GS, Mwangi JM
Reference: 
Malaria Journal 2010, 9:170 (17 June 2010)

The new method for parasite synchronization results in highly synchronized populations of parasites, which will be useful for studies of the parasite asexual cell cycle.

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Open Access | Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection

June 14, 2010 - 13:00 -- Kabogo Ndegwa
Author(s): 
Horton AA, Lee Y, Coulibaly CA, Rashbrook VK, Cornel AJ, Lanzaro GC, Luckhart S
Reference: 
Malaria Journal 2010, 9:160 (11 June 2010)

Seven of these eight infection-associated and linked SNPs alter codon frequency or introduce non-synonymous changes that would be predicted to alter protein structure and, hence, function, suggesting that these SNPs could alter immune signaling and responsiveness to parasite infection.

Expression, purification and characterization of allelic variants of MSP-142 from Indian Plasmodium falciparum isolates

June 14, 2010 - 12:57 -- Patrick Sampao
Author(s): 
P.V. Lalitha, S. Biswas, C.R. Pillai, R.K. Seth, R.K. Saxena
Reference: 
Vaccine, Volume 28, Issue 29, 23 June 2010, Pages 4661-4667

The C-terminal 19 and 42 kDa fragments of Plasmodium falciparum merozoite surface protein 1 (MSP-1) have shown to be protective in animals against lethal parasite challenge.

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Open Access | Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum

June 11, 2010 - 08:35 -- Patrick Sampao
Author(s): 
Salgueiro P, Vicente JL, Ferreira C, Teofilo V, Galvao A, do Rosario VE, Cravo P, Pinto J
Reference: 
BMC Infectious Diseases 2010, 10:163 (9 June 2010)

This study provides additional evidence for the crucial role of gene flow and drug selective pressures in the rapid spread of SP resistance in P. falciparum populations, from only a few mutation events giving rise to resistance-associated mutants.

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Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP142

June 10, 2010 - 08:14 -- Patrick Sampao
Author(s): 
Richard Weiss, Maximilian Gabler, Thomas Jacobs, Tim-Wolf Gilberger, Josef Thalhamer, Sandra Scheiblhofer
Reference: 
Vaccine, Volume 28, Issue 28, 17 June 2010, Pages 4515-4522

In this work, C3d exerted differential effects on humoral immune responses after gene gun immunization of mice with plasmids encoding the malaria blood stage antigen MSP142 depending on the nature of the protein Plasmodium falciparum vs. Plasmodium berghei MSP), the localization of the C3d moiety (C-terminal vs. N-terminal), and the presence of putative N-glycosylation sites.

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