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Falciparum

Open Access | SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

September 13, 2010 - 12:51 -- Kabogo Ndegwa
Author(s): 
Abdirahman Abdi, Sylvain Eschenlauer, Luc Reininger & Christian Doerig
Reference: 
Cellular and Molecular Life Sciences Volume 67, Number 19, 3355-3369

Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases.

Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells

September 10, 2010 - 14:35 -- Patrick Sampao
Author(s): 
Martin M., Rebecca A., et al.
Reference: 
Cellular Microbiology, Volume 12, Issue 10, pages 1446–1462, October 2010

This study establishes a new system to investigate PfEMP1 transport and demonstrates that the PfEMP1 semi-conserved head structure is under selection for protein transport, in addition to its known roles in adhesion.

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Open Access | Clinical Trials and Observations: High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

September 10, 2010 - 13:29 -- Kabogo Ndegwa
Author(s): 
Charlotte F. McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H. Opi, Carolyne Ndila, Antony Ngatia, John Anthony G. Scott, Kevin Marsh, and Thomas N. Williams
Reference: 
Blood, 9 September 2010, Vol. 116, No. 10, pp. 1663-1668.

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya.

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Open Access | Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

July 29, 2010 - 11:46 -- Kabogo Ndegwa
Author(s): 
Marta C. Nunes, Mami Okada, Christine Scheidig-Benatar, Brian M. Cooke, Artur Scherf
Reference: 
PLoS ONE 5(7): e11747

Our results suggest that FIKK members phosphorylate different membrane skeleton proteins of the infected erythrocyte in a stage-specific manner, inducing alterations in the mechanical properties of the parasite-infected red blood cell.

Open Access | An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes

July 13, 2010 - 13:22 -- Kabogo Ndegwa
Author(s): 
Ghosh AK, Dinglasan RR, Ikadai H, Jacobs-Lorena M
Reference: 
Malaria Journal 2010, 9:194 (8 July 2010)

This simple and practical improvement over the prevailing methodology will facilitate the investigation of how this important human malaria parasite initiates its development in the mosquito and will contribute to the understanding of its transmission biology.

Open Access | Malaria rapid diagnostic tests: Plasmodium falciparum infections with high parasite densities may generate false positive Plasmodium vivax pLDH lines

July 12, 2010 - 14:50 -- Kabogo Ndegwa
Author(s): 
Maltha J, Gillet P, Cnops L, van den Ende J, van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2010, 9:198 (10 July 2010)

False positive Pv-pLDH lines in P. falciparum samples with high parasite density occurred in 6/9 P. vivax-specific RDTs. This is of concern as P. falciparum and P. vivax are co-circulating in many regions. The diagnosis of life-threatening P. falciparum malaria may be missed (two-band Pv-pLDH RDT), or the patient may be treated incorrectly with primaquine (three- or four-band RDTs).

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Open Access | Malaria parasite genome scan: insights into antimalarial resistance

July 12, 2010 - 14:29 -- Kabogo Ndegwa
Author(s): 
Bhavna Gupta, Gauri Awasthi and Aparup Das
Reference: 
Parasitology Research, Volume 107, Number 2 / July, 2010

Genome scan and genotype-phenotype association study offer excellent opportunities to unearth drug/vaccine targets in human pathogens including malaria parasites.

Open Access | Prevalence of Plasmodium vivax VK210 and VK247 subtype in Myanmar

July 12, 2010 - 13:47 -- Kabogo Ndegwa
Author(s): 
Kim T, Kim H, Lee S, Na B, Lin K, Cho S, Kang Y, Kim D, Sohn Y, Kim H, Lee H
Reference: 
Malaria Journal 2010, 9:195 (9 July 2010)

The proportion of the VK247 subtype in Myanmar was 43.1% (n=25) among 58 positive cases by serodiagnosis and 25.6% (n=24) among 94 positive cases by genetic diagnosis. In both diagnostic methods, the infection status of malaria patients is highly diverse with respect to malaria species, and multiple clonal infections are prevalent in Myanmar.

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Intravenous Ibuprofen (IV-ibuprofen) Controls Fever Effectively in Adults with Acute Uncomplicated Plasmodium falciparum Malaria but Prolongs Parasitemia

July 2, 2010 - 13:39 -- Patrick Sampao
Author(s): 
Srivicha K., Noppadon T., et al.
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 51 - 55.

Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine.

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Open Access | Disorders of Iron Metabolism: Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

July 1, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Reference: 
Haematologica, July 2010; 95: 1068 - 1074.

Asymptomatic malarial parasitemia is associated with increased hepcidin concentrations and anemia, in the absence of a manifest acute phase response.

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