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Falciparum

New imidazolidinedione derivatives as antimalarial agents

February 15, 2011 - 11:45 -- Kabogo Ndegwa
Author(s): 
Liang Zhang, Ramadas Sathunuru, ThuLan Luong, Victor Melendez, Michael P. Kozar, Ai J. Lin
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 4, 15 February 2011, Pages 1541-1549

A series of new N-alky- and N-alkoxy-imidazolidinediones was prepared and assessed for prophylactic and radical curative activities in mouse and Rhesus monkey models.

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Open Access | Anaemia in a phase 2 study of a blood stage falciparum malaria vaccine

January 20, 2011 - 12:13 -- Kabogo Ndegwa
Author(s): 
Ellis RD, Fay MP, Sagara I, Dicko A, Miura K, Guindo MA, Guindo A, Sissoko MS, Doumbo OK, Diallo D
Reference: 
Malaria Journal 2011, 10:13 (19 January 2011)

While these additional analyses show a robust effect of vaccination on anaemia, this is an intensive exploration of secondary results and should, therefore, be interpreted with caution.

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Open Access | Pharmacokinetics and Disposition: Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

January 14, 2011 - 12:37 -- Patrick Sampao
Author(s): 
Elizabeth A. Ashley., Kasia Stepniewska.,François Nosten., et al.
Reference: 
European Journal of Clinical Pharmacology, Volume 66, Number 7, 705-712

The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma.

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Open Access | Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea

December 16, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Rosanas-Urgell A, Mueller D, Betuela I, Barnadas C, Iga J, Zimmerman PA, del Portillo HA, Siba P, Mueller I, Felger I
Reference: 
Malaria Journal 2010, 9:361 (14 December 2010)

The qPCR assay developed proved optimal for detection of all four Plasmodium species.

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Open Access | Review: What is the evidence for the existence of Plasmodium ovale hypnozoites?

November 19, 2010 - 11:13 -- Kabogo Ndegwa
Author(s): 
Joachim Richter, Gabriele Franken, Heinz Mehlhorn, Alfons Labisch and Dieter Häussinger
Reference: 
Parasitology Research, 2010, Volume 107, Number 6, Pages 1285-1290

Relapsing human malaria is regarded to be caused by Plasmodium vivax and Plasmodium ovale. P. vivax relapses originate from dormant liver stages: “hypnozoites”. Also, P. ovale, a species considered as closely related to P. vivax, is in analogy assumed to display hypnozoites.

Fast Track: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

November 15, 2010 - 13:43 -- Patrick Sampao
Author(s): 
Arjen M Dondorp, Caterina I Fanello, Juliet Mwanga-Amumpaire et al.
Reference: 
The Lancet, Volume 376, Issue 9753, 13 November 2010-19 November 2010, Pages 1647-1657

These data, together with a meta-analysis of all trials comparing artesunate and quinine, strongly suggest that parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide.

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Pharmacology: Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania

October 18, 2010 - 09:40 -- Patrick Sampao
Author(s): 
Sofia F., Andreas M., et al.
Reference: 
Antimicrob. Agents Chemother., Nov 2010; 54: 4780 - 4788.

The aim of this analysis was to describe the pharmacokinetics and pharmacodynamics of artemether, dihydroartemisinin, and lumefantrine in African children with uncomplicated malaria.

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Open Access | Severe Imported Falciparum Malaria: A Cohort Study in 400 Critically Ill Adults

October 18, 2010 - 08:52 -- Patrick Sampao
Author(s): 
Fabrice B., Florence T., et al.
Reference: 
PLoS ONE 5(10): e13236.

Data from 400 adults admitted to the intensive care unit were analysed, representing the largest series of severe imported malaria to date. Median age was 45 years; 60% of patients were white, 96% acquired the disease in sub-Saharan Africa, and 65% had not taken antimalarial chemoprophylaxis.

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Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial

September 29, 2010 - 08:31 -- Patrick Sampao
Author(s): 
Frank S., Moe K., et al.
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 10, October 2010, Pages 673-681

We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of .

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Open Access | Neopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria

September 15, 2010 - 14:01 -- Kabogo Ndegwa
Author(s): 
Rene te Witt R, van Wolfswinkel ME, Petit PL, van Hellemond JJ, Koelewijn R, van Belkum A, van Genderen PJ
Reference: 
Malaria Journal 2010, 9:255 (14 September 2010)

Although the diagnostic value of neopterin and procalcitonin is limited, the high negative predictive value of both neopterin and procalcitonin may be helpful for a rapid exclusion of severe malaria disease on admission.

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