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Falciparum

Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria

September 15, 2011 - 12:03 -- Patrick Sampao
Author(s): 
Sarah J Higgins, Kevin C Kain and W Conrad Liles
Reference: 
Expert Review of Anti-infective Therapy, September 2011, Vol. 9, No. 9, Pages 803-819

In this article, we summarize immunomodulatory therapies that have been assessed in clinical trials to date, and highlight novel and promising treatment strategies currently being investigated to address this major global health challenge.

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Prolonged Selection of pfmdr1 Polymorphisms After Treatment of Falciparum Malaria With Artemether-Lumefantrine in Uganda

September 2, 2011 - 13:14 -- Patrick Sampao
Author(s): 
Frederick N. Baliraine and Philip J. Rosenthal
Reference: 
J Infect Dis. (2011) 204 (7): 1120-1124.

We compared the prevalence of key pfmdr1 alleles between pretreatment Plasmodium falciparum parasite isolates and parasites that emerged after treatment of uncomplicated malaria in a longitudinal cohort of Ugandan children.

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Open Access | Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area

August 16, 2011 - 09:21 -- Kabogo Ndegwa
Author(s): 
Song J, Socheat D, Tan B, Seila S, Xu Y, Ou F, Sokunthea S, Sophorn L, Zhou C, Deng C, Wang Q, Li G
Reference: 
Malaria Journal 2011, 10:231 (10 August 2011)

AP, DHP and AL all remained efficacious treatments for the treatment of falciparum malaria in Cambodia-Thailand border area.

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Open Access | How Much Remains Undetected? Probability of Molecular Detection of Human Plasmodia in the Field

July 6, 2011 - 08:27 -- Kabogo Ndegwa
Author(s): 
Cristian Koepfli, Sonja Schoepflin, Michael Bretscher, Enmoore Lin, Benson Kiniboro, Peter A. Zimmerman, Peter Siba, Thomas A. Smith, Ivo Mueller, Ingrid Felger
Reference: 
PLoS ONE 6(4): e19010

In malaria endemic areas, most people are simultaneously infected with different parasite clones. Detection of individual clones is hampered when their densities fluctuate around the detection limit and, in case of P. falciparum, by sequestration during part of their life cycle.

Open Access | Coma Associated with Microscopy-Diagnosed Plasmodium vivax: A Prospective Study in Papua, Indonesia

June 9, 2011 - 07:35 -- Kabogo Ndegwa
Author(s): 
Daniel A. Lampah, Tsin W. Yeo, Setiawan O. Hardianto, Emiliana Tjitra, Enny Kenangalem, Paulus Sugiarto, Ric N. Price, Nicholas M. Anstey
Reference: 
PLoS Negl Trop Dis 5(6): e1032

P. vivax-associated coma is rare, occurring 23 times less frequently than that seen with falciparum malaria, and is associated with a high proportion of non-malarial causes and mixed infections using PCR.

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Open Access | Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast

May 23, 2011 - 14:28 -- Patrick Sampao
Author(s): 
Symon M. Kariuki, Michelle Ikumi, Charles R. J. C. Newton, et al.
Reference: 
Brain (2011) 134 (5): 1519-1528.

We examined the changes in the incidence of seizures with the reduction of malaria. Logistic regression was used to model malaria-attributable fractions for seizures (the proportion of seizures caused by malaria) to determine if the observed decrease in acute symptomatic seizures was a measure of seizures that are attributable to malaria.

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Anti-malarial drug formulations and novel delivery systems: A review

May 4, 2011 - 11:45 -- Kabogo Ndegwa
Author(s): 
P. Murambiwa, B. Masola, T. Govender, S. Mukaratirwa, C.T. Musabayane
Reference: 
Acta Tropica, Volume 118, Issue 2, May 2011, Pages 71-79

Artemisinin combination therapies have decreased malaria associated morbidity and mortality in several parts of the world.

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Standardised versus actual white cell counts in estimating thick film parasitaemia in African children under five

April 20, 2011 - 07:43 -- Kabogo Ndegwa
Author(s): 
Piero Olliaro, Abdoulaye Djimdé, Corine Karema, Andreas Mårtensson, Jean-Louis Ndiaye, Sodiomon B. Sirima, Grant Dorsey and Julien Zwang
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 5, pages 551–554, May 2011

In patients with malaria, parasitaemia is usually estimated by assuming 8000 white cell counts (WCC) per microlitre of blood.

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Open Access | Learning from errors: Falciparum malaria masquerading as appendicitis

March 15, 2011 - 14:21 -- Patrick Sampao
Author(s): 
Anand Kumar Bhardwaj, P D Sharma, Akshay Sharma
Reference: 
BMJ Case Reports

Here is an unusual case of falciparum malaria presenting as acute appendicitis. This case did not respond to artemether therapy and that also points towards drug resistance emerging in malaria.

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Open Access | PvRON2, a new Plasmodium vivax rhoptry neck antigen

March 15, 2011 - 08:57 -- Kabogo Ndegwa
Author(s): 
Arevalo-Pinzon G, Curtidor H, Patino LC, Patarroyo MA
Reference: 
Malaria Journal 2011, 10:60 (14 March 2011)

The identification and partial characterization of the first P. vivax rhoptry neck protein are described in the present study.

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