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rodent malaria

Open Access | Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)

April 2, 2012 - 14:20 -- Patrick Sampao
Author(s): 
Lawton J, Brugat T, Yam X, Reid AJ, Boehme U, Otto TD, Pain A, Jackson A, Berriman M, Cunningham D, Preiser P, Langhorne J
Reference: 
BMC Genomics 2012, 13:125 (29 March 2012)

MalariaWorldIn this model, pir genes are called cirs and may be involved in this mechanism, allowing evasion of host immune responses. In order to fully understand the role(s) of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required.

Open Access | Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

March 22, 2012 - 12:33 -- Patrick Sampao
Author(s): 
Katarzyna KINGA Modrzynska, Alison Creasey, Paul Hunt, et al.
Reference: 
BMC Genomics 2012, 13:106

MalariaWorldTo address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.

Medical Treatment: 

Open Access | Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging

December 12, 2009 - 12:40 -- Ingeborg van Schayk
Author(s): 
Ploemen IHJ, Prudêncio M, Douradinha BG, Ramesar J, Fonager J, et al.
Reference: 
PLoS ONE 4(11): e7881

Here we report the use of a transgenic P. berghei parasite, PbGFP-Luccon, expressing the bioluminescent reporter protein luciferase to visualize and quantify parasite development in liver cells both in culture and in live mice using real-time luminescence imaging.

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