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Open Access | Arm-in-cage testing of natural human-derived mosquito repellents

August 23, 2010 - 13:21 -- Kabogo Ndegwa
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Author(s): 
Logan JG, Stanczyk NM, Hassanali A, Kemei J, Santana AE, Ribeiro KA, Pickett JA, Mordue (Luntz) A
Reference: 
Malaria Journal 2010, 9:239 (20 August 2010)

The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel repellents for personal protection.

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Open Access | Relevant microclimate for determining the development rate of malaria mosquitoes and possible implications of climate change

July 12, 2010 - 13:53 -- Kabogo Ndegwa
Author(s): 
Paaijmans KP, Imbahale SS, Thomas MB, Takken W
Reference: 
Malaria Journal 2010, 9:196 (9 July 2010)

Existing models will tend to underestimate mosquito population growth under current conditions, and may overestimate relative increases in population growth under future climate change. These results highlight the need for better integration of biological and environmental information at the scale relevant to mosquito biology.

Evaluation of Four Methods for Collecting Malaria Vectors in French Guiana

July 1, 2010 - 09:32 -- Kabogo Ndegwa
Author(s): 
Dusfour I, Carinci R, Gaborit P, Issaly J, Girod R.
Reference: 
Journal of Economic Entomology Jun 2010: Vol. 103, Issue 3, pg(s) 973-976

In French Guiana, malaria transmission is mainly due to Anopheles darlingi Root, but other species also are involved. Investigation and surveillance must be carried out on all the species to unravel malaria transmission patterns.

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An exploratory survey of malaria prevalence and people's knowledge, attitudes and practices of mosquito larval source management for malaria control in western Kenya

June 9, 2010 - 08:18 -- Kabogo Ndegwa
Author(s): 
S.S. Imbahale, U. Fillinger, A. Githeko, W.R. Mukabana, W. Takken
Reference: 
Acta Tropica, Volume 115, Issue 3, September 2010, Pages 248-256

A large proportion of mosquito larval habitats in urban and rural communities in sub-Saharan Africa are man-made. Therefore, community-based larval source management (LSM) could make a significant contribution to malaria control in an integrated vector management approach.

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Open Access | Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy

May 31, 2010 - 11:48 -- Kabogo Ndegwa
Author(s): 
Leitner WW, Bergmann-Leitner ES, Angov E
Reference: 
Malaria Journal 2010, 9:145 (27 May 2010)

The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of parasite, and are poorly understood. A challenge with live parasites is the most relevant approach to testing the efficacy of experimental malaria vaccines.

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Inbreeding depression affects life-history traits but not infection by Plasmodium gallinaceum in the Asian tiger mosquito, Aedes albopictus

May 27, 2010 - 11:36 -- Patrick Sampao
Author(s): 
Deborah O’Donnell, Peter Armbruster
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 669-677

We suggest that additional research is needed to elucidate the genetic underpinnings of intraspecific variation in traits related to disease transmission and discuss the implications of our results for the efficacy of creating transgenic strains refractory to disease transmission.

Open Access | Research: The Importance of Age Dependent Mortality and the Extrinsic Incubation Period in Models of Mosquito-Borne Disease Transmission and Control

April 16, 2010 - 08:15 -- Kabogo Ndegwa
Author(s): 
Steve E. Bellan
Reference: 
PLoS ONE 5(4): e10165.

Interventions that reduce mosquito survival were also found to be slightly less effective when implemented in systems with shorter EIPs. Future transmission models that examine anti-vectorial interventions should incorporate realistic age dependent mortality rates.

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Structure and Function of a G-actin Sequestering Protein with a Vital Role in Malaria Oocyst Development inside the Mosquito Vector

April 9, 2010 - 06:37 -- Patrick Sampao
Author(s): 
Marion Hliscs, Julia M. Sattler, Wolfram Tempe, Jennifer D. Artz, Aiping Dong, Raymond Hui, Kai Matuschewski, Herwig Schüle
Reference: 
The Journal of Biological Chemistry

Our results reveal a specific vital role for an apicomplexan G-actin-binding protein during sporogony, the parasite replication phase that precedes formation of malaria transmission stages. 

Is Mosquito Larval Source Management Appropriate for Reducing Malaria in Areas of Extensive Flooding in The Gambia? A Cross-over Intervention Trial

February 10, 2010 - 13:19 -- Ingeborg van Schayk
Author(s): 
Silas Majambere, Margaret Pinder, Ulrike Fillinger, David Ameh, David J. Conway, Clare Green, David Jeffries, Musa Jawara, Paul J. Milligan, Robert Hutchinson, AND Steven W. Lindsay
Reference: 
Am J Trop Med Hyg 2010;82 176-184

Larviciding to control malaria was assessed in rural areas with extensive seasonal flooding. Larval and adult mosquitoes and malaria incidence were surveyed routinely in four 100-km2 areas either side of the Gambia River.

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Review: Mosquito immune defenses against Plasmodium infection

February 4, 2010 - 15:19 -- Kabogo Ndegwa
Author(s): 
Chris M. Cirimotich, Yuemei Dong, Lindsey S. Garver, Shuzhen Sim, George Dimopoulos
Reference: 
Developmental & Comparative Immunology, Volume 34, Issue 4, April 2010, Pages 387-395

The causative agent of malaria Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. 

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