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chloroquine (CQ) resistance

NOT Open Access | Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites

April 14, 2015 - 17:29 -- NOT Open Access
Ehab Mossaad, Wakako Furuyama, Masahiro Enomoto, Satoru Kawai, Katsuhiko Mikoshiba, and Shin-ichiro Kawazu
Antimicrob. Agents Chemother. May 2015 vol. 59 no. 5 2890-2892

A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB).

Medical Condition: 

Tracking Origins and Spread of Sulfadoxine-Resistant Plasmodium falciparum dhps Alleles in Thailand

December 28, 2010 - 10:02 -- Kabogo Ndegwa
Md Tauqeer Alam, Sumiti Vinayak, Kanungnit Congpuong, Chansuda Wongsrichanalai, Wichai Satimai, Laurence Slutsker, Ananias A. Escalante, John W. Barnwell, and Venkatachalam Udhayakumar
Antimicrobial Agents and Chemotherapy, January 2011, p. 155-164, Vol. 55, No. 1

The emergence and spread of drug-resistant Plasmodium falciparum have been a major impediment for the control of malaria worldwide.

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