A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB).
chloroquine (CQ) resistance
Antimicrob. Agents Chemother. May 2015 vol. 59 no. 5 2890-2892
Antimicrobial Agents and Chemotherapy, January 2011, p. 155-164, Vol. 55, No. 1
The emergence and spread of drug-resistant Plasmodium falciparum have been a major impediment for the control of malaria worldwide.