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chloroquine (CQ) resistance

NOT Open Access | Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites

April 14, 2015 - 17:29 -- NOT Open Access
Author(s): 
Ehab Mossaad, Wakako Furuyama, Masahiro Enomoto, Satoru Kawai, Katsuhiko Mikoshiba, and Shin-ichiro Kawazu
Reference: 
Antimicrob. Agents Chemother. May 2015 vol. 59 no. 5 2890-2892

A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB).

Medical Condition: 

Tracking Origins and Spread of Sulfadoxine-Resistant Plasmodium falciparum dhps Alleles in Thailand

December 28, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Md Tauqeer Alam, Sumiti Vinayak, Kanungnit Congpuong, Chansuda Wongsrichanalai, Wichai Satimai, Laurence Slutsker, Ananias A. Escalante, John W. Barnwell, and Venkatachalam Udhayakumar
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 155-164, Vol. 55, No. 1

The emergence and spread of drug-resistant Plasmodium falciparum have been a major impediment for the control of malaria worldwide.

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