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quinoline resistance

Open Access | Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum

December 1, 2010 - 05:15 -- Kabogo Ndegwa
Author(s): 
Pradines B, Briolant S, Henry M, Oeuvray C, Baret E, Amalvict R, Didillon E, Rogier C
Reference: 
Malaria Journal 2010, 9:339 (25 November 2010)

There was an absence of cross-resistance between pyronaridine and quinolines, and the IC50 values for pyronaridine were found to be unrelated to mutations in the transport protein genes pfcrt, pfmdr1, pfmrp or pfnhe-1, known to be involved in quinoline resistance.

Medical Treatment: 
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