The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10623 malaria professionals are enjoying the free benefits of MalariaWorld today

Plasmodium

Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites

November 23, 2010 - 09:54 -- Patrick Sampao
Author(s): 
Bo Jiang, Li Qin, Yanhua Du, Nanzheng Peng, Ling Chen, Zhiwei Chen, Xiaoping Chen
Reference: 
Vaccine, Volume 28, Issue 50, 23 November 2010, Pages 7915-7922

We demonstrated a novel vaccination strategy that uses a live transgenic protozoan parasite-based bivalent vaccine to immunize mice and confer significant levels of protection against VV-gag and malarial parasite challenges.

Medical Condition: 
Medical Treatment: 

Informed decision-making before changing to RDT: a comparison of microscopy, rapid diagnostic test and molecular techniques for the diagnosis and identification of malaria parasites in Kassala, eastern Sudan

November 23, 2010 - 07:15 -- Kabogo Ndegwa
Author(s): 
Mamoun M. M. Osman, Bakri Y. M. Nour, Mohamed F. Sedig, Laura De Bes, Adil M. Babikir, Ahmed A. Mohamedani and Petra F. Mens
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 12, pages 1442–1448, December 2010

PCR has proven to be one of the most specific and sensitive diagnostic methods, particularly for malaria cases with low parasitaemia.

Country: 
Medical Condition: 
Medical Treatment: 

Case Reports: Complication of Corticosteroid Treatment by Acute Plasmodium malariae Infection Confirmed by Small-Subunit rRNA Sequencing

November 5, 2010 - 09:22 -- Patrick Sampao
Author(s): 
Kelvin K. W. To, Jade L. L. Teng, Samson S. Y. Wong, Antonio H. Y. Ngan, Kwok-Yung Yuen, and Patrick C. Y. Woo
Reference: 
J. Clin. Microbiol., Nov 2010; 48: 4313 - 4316.

We report a case of acute Plasmodium malariae infection complicating corticosteroid treatment for membranoproliferative glomerulonephritis in a patient from an area where P. malariae infection is not endemic.

Medical Condition: 
Medical Treatment: 

Open Access | Invited Speaker Presentation: Plasmodium-Host-Plasmodium interactions

November 3, 2010 - 13:24 -- Patrick Sampao
Author(s): 
Maria M Mota
Reference: 
Malaria Journal 2010, 9(Suppl 2):I8 (20 October 2010)

Mosquito bites transmit liver-tropic sporozoites into subjects who are still infected from a previous mosquito bite. What is the impact of ongoing infection in the establishment of a secondary infection is unknown.

Person: 
Medical Condition: 

Malaria Vaccine Design: Immunological Considerations

November 2, 2010 - 08:36 -- Kabogo Ndegwa
Author(s): 
Michael F. Good, Denise L. Doolan
Reference: 
Immunity, Volume 33, Issue 4, 29 October 2010, Pages 555-566

The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one.

Medical Condition: 
Medical Treatment: 

Open Access | Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae

November 2, 2010 - 08:11 -- Kabogo Ndegwa
Author(s): 
Zakaria Kambris, Andrew M. Blagborough, Sofia B. Pinto, Marcus S. C. Blagrove, H. Charles J. Godfray, Robert E. Sinden, Steven P. Sinkins
Reference: 
Pathog 6(10): e1001143

The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes.

Open Access | Heritability of Plasmodium Parasite Density in a Rural Ugandan Community

November 1, 2010 - 14:09 -- Patrick Sampao
Author(s): 
Rachel L. Pullan, Hasifa Bukirwa, Robert W. Snow, AND Simon Brooker
Reference: 
Am J Trop Med Hyg, Nov 2010; 83: 990 - 995.

Here, we examine the roles of host genetics and exposure in determining parasite density, and test whether effects differ with age.

Country: 
Region: 
Medical Condition: 

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections

October 18, 2010 - 09:25 -- Patrick Sampao
Author(s): 
Deniz T., David S., et al.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 21, 1 November 2010, Pages 7475-7485

This is the first study to indicate therapeutic potential of HDAs against various parasitic protozoa. It also points out that the malarial liver stage growth inhibitory effect of the 2-HDA may be promoted via PfFAS-II enzymes.

Open Access | Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae

October 15, 2010 - 14:28 -- Patrick Sampao
Author(s): 
Zakaria Kambris, Andrew M. Blagborough, Sofia B. Pinto, Marcus S. C. Blagrove, H. Charles J. Godfray, Robert E. Sinden, Steven P. Sinkins
Reference: 
Plos Pathogens Volume 6 Issue 10 2010

The data are discussed with respect to the comparative effects on malaria vectorial capacity of life shortening and direct inhibition of Plasmodium development that can be produced by Wolbachia.

Medical Condition: 
Medical Treatment: 

Open Access | The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes

October 4, 2010 - 09:19 -- Kabogo Ndegwa
Author(s): 
Ursula Straschil, Arthur M. Talman, David J. P. Ferguson, Karen A. Bunting, Zhengyao Xu, Elizabeth Bailes, Robert E. Sinden, Anthony A. Holder, Elizabeth F. Smith, Juliet C. Coates, Rita Tewari
Reference: 
PLoS ONE 5(9): e12901

Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world's population. Transmission between vertebrate and insect hosts depends on the sexual stages of the life-cycle.

Medical Condition: 

Pages

Subscribe to RSS - Plasmodium