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Plasmodium

Open Access | Analysis of Two Novel Midgut-Specific Promoters Driving Transgene Expression in Anopheles stephensi Mosquitoes

February 9, 2011 - 08:54 -- Kabogo Ndegwa
Author(s): 
Tony Nolan, Elisa Petris, Hans-Michael Müller, Ann Cronin, Flaminia Catteruccia, Andrea Crisanti
Reference: 
PLoS ONE 6(2): e16471

Our studies on two putative blood-meal induced, midgut-specific promoters validate the use of G12 upstream regulatory regions to drive targeted transgene expression coinciding spatially and temporally with pre-sporogonic stages of Plasmodium parasites in the mosquito, offering the possibility of manipulating vector competence or performing functional studies on vector-parasite interactions.

Review: Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

February 2, 2011 - 13:53 -- Patrick Sampao
Author(s): 
Xavier C. Ding, Hans-Peter Beck, Giovanna Raso
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 73-81

In this review different models of artemisinins’ molecular action are briefly presented, focusing on recent advances, and the evidence of potential association between various gene polymorphisms and artemisinin resistance is comprehensively reviewed.

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Open Access | Site-Specific Integration and Expression of an Anti-Malarial Gene in Transgenic Anopheles gambiae Significantly Reduces Plasmodium Infections

February 2, 2011 - 06:33 -- Kabogo Ndegwa
Author(s): 
Janet M. Meredith, Sanjay Basu, Derric D. Nimmo, Isabelle Larget-Thiery, Emma L. Warr, Ann Underhill, Clare C. McArthur, Victoria Carter, Hilary Hurd, Catherine Bourgouin, Paul Eggleston
Reference: 
PLoS ONE 6(1): e14587

Diseases transmitted by mosquitoes have a devastating impact on global health and this is worsening due to difficulties with existing control measures and climate change.

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Review: The Apicomplexan AP2 family: Integral factors regulating Plasmodium development

January 25, 2011 - 06:59 -- Patrick Sampao
Author(s): 
Heather J. Painter, Tracey L. Campbell, Manuel Llinás
Reference: 
Molecular and Biochemical Parasitology, Volume 176, Issue 1, March 2011, Pages 1-7

Here we highlight recent progress toward understanding the role of Plasmodium ApiAP2 proteins in DNA related regulatory processes including transcriptional regulation and gene silencing.

Short Communication: The hypnozoite concept, with particular reference to malaria

January 5, 2011 - 07:39 -- Kabogo Ndegwa
Author(s): 
Miles B. Markus
Reference: 
Parasitology Research, Vol. 108, Issue 1, Pages 247-252

In 1978, the nature of the hypnozoite was discussed in an article that appeared in a relatively obscure journal, which is also where the term was adopted for Plasmodium (a little-known fact).

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Open Access | Insecticide resistance and malaria transmission: infection rate and oocyst burden in Culex pipiens mosquitoes infected with Plasmodium relictum

January 4, 2011 - 12:42 -- Kabogo Ndegwa
Author(s): 
Vezilier J, Nicot A, Gandon S, Rivero A
Reference: 
Malaria Journal 2010, 9:379 (31 December 2010)

Insecticide resistance was found to have no effect on Plasmodium development within the mosquito.

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Review: Central carbon metabolism of Plasmodium parasites

December 20, 2010 - 10:41 -- Patrick Sampao
Author(s): 
Kellen L. Olszewski, Manuel Llinás
Reference: 
Molecular and Biochemical Parasitology, Volume 175, Issue 2, February 2011, Pages 95-103

We focus primarily on the blood stages of Plasmodium falciparum, the most lethal of the human malaria parasites, but also integrate results from simian, avian and rodent models of malaria that were a major focus of early investigations into plasmodial metabolism.

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Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico

December 20, 2010 - 09:48 -- Patrick Sampao
Author(s): 
Segun Fatumo, Kitiporn Plaimas, Ezekiel Adebiyi, Rainer König
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 1, January 2011, Pages 201-208

Comparing the modeling results with a comprehensive list of known drug targets for P. falciparum, showed that we had the best discovery success with a network model consisting only of enzymes from the parasite alone which coding genes were known.

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Open Access | Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea

December 16, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Rosanas-Urgell A, Mueller D, Betuela I, Barnadas C, Iga J, Zimmerman PA, del Portillo HA, Siba P, Mueller I, Felger I
Reference: 
Malaria Journal 2010, 9:361 (14 December 2010)

The qPCR assay developed proved optimal for detection of all four Plasmodium species.

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Open Access | Dispatch: Wild Chimpanzees Infected with 5 Plasmodium Species

November 30, 2010 - 10:12 -- Patrick Sampao
Author(s): 
Marco Kaiser, Anna Löwa., Fabian H. Leendertz., et al
Reference: 
Emerging Infectious Diseases ,Volume 16, Number 12–December 2010

We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ovale, P. reichenowi, and P. gaboni.

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