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Plasmodium

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

May 4, 2011 - 11:40 -- Kabogo Ndegwa
Author(s): 
Ana Ferreira, Ivo Marguti, Ingo Bechmann, Viktória Jeney, Ângelo Chora, Nuno R. Palha, Sofia Rebelo, Annie Henri, Yves Beuzard, Miguel P. Soares
Reference: 
Cell, Volume 145, Issue 3, 29 April 2011, Pages 398-409

Sickle human hemoglobin (Hb) confers a survival advantage to individuals living in endemic areas of malaria, the disease caused by Plasmodium infection.

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Review: A plethora of Plasmodium species in wild apes: a source of human infection?

April 29, 2011 - 10:43 -- Patrick Sampao
Author(s): 
Julian C. Rayner, Weimin Liu, Martine Peeters, Paul M. Sharp, Beatrice H. Hahn
Reference: 
Trends in Parasitology, Volume 27, Issue 5, May 2011, Pages 222-229

These findings raise the question whether wild apes could be a recurrent source of Plasmodium infections in humans. This question is not new, but was the subject of intense investigation by researchers in the first half of the last century.

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Highly conserved gene arrangement of the mitochondrial genomes of 23 Plasmodium species

April 12, 2011 - 14:05 -- Patrick Sampao
Author(s): 
Kenji Hikosaka, Yoh-ichi Watanabe, Fumie Kobayashi, Seiji Waki, Kiyoshi Kita, Kazuyuki Tanabe
Reference: 
Parasitology International, Volume 60, Issue 2, June 2011, Pages 175-180

In this study, we determined the arrangement of mt rRNA gene fragments in 23 Plasmodium species, including two newly determined mt genome sequences from P. gallinaceum and P. vinckei vinckei, as well as Leucocytozoon caulleryi, an outgroup of Plasmodium.

Open Access | Rapid diagnostic tests as a source of DNA for Plasmodium species-specific real-time PCR

March 28, 2011 - 12:22 -- Kabogo Ndegwa
Author(s): 
Cnops L, Boderie M, Gillet P, Van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2011, 10:67 (24 March 2011)

RDTs are a reliable source of DNA for Plasmodium real-time PCR. This study demonstrates the best method of RDT fragment sampling for a wide range of RDT brands in combination with a simple and low cost extraction method, allowing RDT quality control.

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Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth

March 22, 2011 - 10:01 -- Kabogo Ndegwa
Author(s): 
Sanjeev Chandel & Upma Bagai
Reference: 
Parasitology Research, Volume 108, Number 4, 801-805

The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action.

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Open Access | Dendritic Cells and Hepatocytes Use Distinct Pathways to Process Protective Antigen from Plasmodium in vivo

March 22, 2011 - 09:04 -- Kabogo Ndegwa
Author(s): 
Ian A. Cockburn, Sze-Wah Tse, Andrea J. Radtke, Prakash Srinivasan, Yun-Chi Chen, Photini Sinnis, Fidel Zavala
Reference: 
PLoS Pathog 7(3): e1001318

Malaria-protective CD8+ T cells specific for the circumsporozoite (CS) protein are primed by dendritic cells (DCs) after sporozoite injection by infected mosquitoes.

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Plasmodium salvages cholesterol internalized by LDL and synthesized de novo in the liver

March 21, 2011 - 06:54 -- Patrick Sampao
Author(s): 
Mehdi Labaied, Bamini Jayabalasingham, Nazneen Bano, Sung-Jae Cha, Juan Sandoval, Guimin Guan, Isabelle Coppens
Reference: 
Cellular Microbiology, Volume 13, Issue 4, pages 569–586, April 2011

These data enlighten that, on one hand, malaria parasites have moderate need of sterols for optimal development in hepatocytes and, on the other hand, they can adapt to survive in cholesterol-restrictive conditions by exploitation of accessible sterols derived from alternative sources in hepatocytes to maintain proper infectivity.

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Open Access | Filarial Worms Reduce Plasmodium Infectivity in Mosquitoes

March 1, 2011 - 06:43 -- Kabogo Ndegwa
Author(s): 
Matthew T. Aliota, Cheng-Chen Chen, Henry Dagoro, Jeremy F. Fuchs, Bruce M. Christensen
Reference: 
PLoS Negl Trop Dis 5(2): e963

These results could have an impact on vector infection and transmission dynamics in areas where Anopheles transmit both parasites, i.e., the elimination of filarial worms in a co-endemic locale could enhance malaria transmission.

Antigen presentation in immunity to murine malaria

February 24, 2011 - 07:35 -- Kabogo Ndegwa
Author(s): 
Rachel J Lundie
Reference: 
Current Opinion in Immunology, Volume 23, Issue 1, February 2011, Pages 119-123

Understanding the initiation of cellular immune responses during blood-stage malaria infection is essential for the development of an effective vaccine that improves upon the naturally acquired immune response and induces rapid and long-lasting protection against disease.

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Open Access | Filarial Worms Reduce Plasmodium Infectivity in Mosquitoes

February 10, 2011 - 11:41 -- Kabogo Ndegwa
Author(s): 
Matthew T. Aliota, Cheng-Chen Chen, Henry Dagoro, Jeremy F. Fuchs, Bruce M. Christensen
Reference: 
PLoS Negl Trop Dis 5(2): e963

These results could have an impact on vector infection and transmission dynamics in areas where Anopheles transmit both parasites, i.e., the elimination of filarial worms in a co-endemic locale could enhance malaria transmission.

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