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Plasmodium

Opinion: A whole parasite vaccine to control the blood stages of Plasmodium – the case for lateral thinking

July 27, 2011 - 15:03 -- Patrick Sampao
Author(s): 
Michael F. Good
Reference: 
Trends in Parasitology, Volume 27, Issue 8, August 2011, Pages 335-340

It is the view of the author that both vaccine paradigms should be pursued, but that success will come more quickly using the paranormal approach of exposing individuals to ultra-low doses of whole attenuated or killed parasites.

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Choice of and Adherence to Prophylactic Antimalarials

July 5, 2011 - 08:19 -- Kabogo Ndegwa
Author(s): 
Larry Goodyer, Leanne Rice and Alan Martin
Reference: 
Journal of Travel Medicine, Volume 18, Issue 4, pages 245–249, July/August 2011

A shorter post-travel regimen has a significant impact on adherence to antimalarial prophylaxis. A reassessment of the risk by travelers on returning home may be a major contributor to this poor adherence.

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Open Access | Environmental Constraints Guide Migration of Malaria Parasites during Transmission

June 22, 2011 - 06:50 -- Kabogo Ndegwa
Author(s): 
Janina Kristin Hellmann, Sylvia Münter, Mikhail Kudryashev, Simon Schulz, Kirsten Heiss, Ann-Kristin Müller, Kai Matuschewski, Joachim P. Spatz, Ulrich S. Schwarz, Friedrich Frischknecht
Reference: 
PLoS Pathog 7(6): e1002080

Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue.

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Open Access | Susceptibility of Anopheles stephensi to Plasmodium gallinaceum: A Trait of the Mosquito, the Parasite, and the Environment

June 21, 2011 - 07:27 -- Kabogo Ndegwa
Author(s): 
Jen C. C. Hume, Howard Hamilton III, Kevin L. Lee, Tovi Lehmann
Reference: 
PLoS ONE 6(6): e20156

The vector's genetics (heritability) comprised 67% of “vector susceptibility” measured by the prevalence of mosquitoes infected with P. gallinaceum oocysts, whereas the specific contribution of parasite genetics (heritability) to this trait was only 5%.

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Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico

June 1, 2011 - 14:34 -- Patrick Sampao
Author(s): 
Segun Fatumo, Kitiporn Plaimas, Ezekiel Adebiyi, Rainer König
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 4, June 2011, Pages 708-715

Plasmodium falciparum causes the most severe malaria pathogen and has developed resistance to existing drugs making it indispensable to discover new drugs. In order to predict drug targets in silico, a useful model for the metabolism is needed.

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Review: Harnessing immune responses against Plasmodium for rational vaccine design

June 1, 2011 - 14:07 -- Patrick Sampao
Author(s): 
Bruno Douradinha, Denise L. Doolan
Reference: 
Trends in Parasitology, Volume 27, Issue 6, June 2011, Pages 274-283

In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application.

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Anopheline species composition in borderline of Iran–Azerbaijan

May 31, 2011 - 11:35 -- Kabogo Ndegwa
Author(s): 
M.A. Oshaghi, H. Vatandoost, A. Gorouhi, M.R. Abai, A. Madjidpour, S. Arshi, H. Sadeghi, M. Nazari, A. Mehravaran
Reference: 
Acta Tropica, Volume 119, Issue 1, July 2011, Pages 44-49

Malaria is still one of the most important health-problems in the world and is endemic in Iran.

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Open Access | The Puf-Family RNA-Binding Protein Puf2 Controls Sporozoite Conversion to Liver Stages in the Malaria Parasite

May 24, 2011 - 08:58 -- Kabogo Ndegwa
Author(s): 
Katja Müller, Kai Matuschewski, Olivier Silvie
Reference: 
PLoS ONE 6(5): e19860

Malaria is a vector-borne infectious disease caused by unicellular, obligate intracellular parasites of the genus Plasmodium.

Open Access | Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery

May 13, 2011 - 12:30 -- Kabogo Ndegwa
Author(s): 
Laurent Dembele, Audrey Gego, Dominique Mazier, et al.
Reference: 
PLoS ONE 6(3): e18162

Resistance of the non-dividing P. cynomolgi forms to atovaquone and pyrimethamine, which do not prevent relapses, strongly suggests that these slow growing forms are hypnozoites.

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Open Access | Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

May 10, 2011 - 08:01 -- Kabogo Ndegwa
Author(s): 
Marcus J Rijken, Machteld E Boel, Bruce Russell, Mallika Imwong, Mara L Leimanis, Aung Pyae Phyo, Atis Muehlenbachs, Niklas Lindegardh, Rose McGready, Laurent Renia, Georges Snounou, Pratap Singhasivanon, Francois Nosten
Reference: 
Malaria Journal 2011, 10:113 (5 May 2011)

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations.

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