It is the view of the author that both vaccine paradigms should be pursued, but that success will come more quickly using the paranormal approach of exposing individuals to ultra-low doses of whole attenuated or killed parasites.
A shorter post-travel regimen has a significant impact on adherence to antimalarial prophylaxis. A reassessment of the risk by travelers on returning home may be a major contributor to this poor adherence.
Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue.
The vector's genetics (heritability) comprised 67% of “vector susceptibility” measured by the prevalence of mosquitoes infected with P. gallinaceum oocysts, whereas the specific contribution of parasite genetics (heritability) to this trait was only 5%.
Plasmodium falciparum causes the most severe malaria pathogen and has developed resistance to existing drugs making it indispensable to discover new drugs. In order to predict drug targets in silico, a useful model for the metabolism is needed.
In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application.
Malaria is still one of the most important health-problems in the world and is endemic in Iran.
Malaria is a vector-borne infectious disease caused by unicellular, obligate intracellular parasites of the genus Plasmodium.
Resistance of the non-dividing P. cynomolgi forms to atovaquone and pyrimethamine, which do not prevent relapses, strongly suggests that these slow growing forms are hypnozoites.
Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations.