The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10568 malaria professionals are enjoying the free benefits of MalariaWorld today

Plasmodium

Open Access | Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage Egress

September 7, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
Stefanie Graewe, Kathleen E. Rankin, Christine Lehmann, Christina Deschermeier, Leonie Hecht, Ulrike Froehlke, Rebecca R. Stanway, Volker Heussler
Reference: 
PLoS Pathog 7(9): e1002224

The protozoan parasite Plasmodium is transmitted by female Anopheles mosquitoes and undergoes obligatory development within a parasitophorous vacuole in hepatocytes before it is released into the bloodstream.

Medical Condition: 

Open Access | Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole

September 7, 2011 - 06:56 -- Kabogo Ndegwa
Author(s): 
Iset Medina Vera, Wandy L. Beatty, Photini Sinnis, Kami Kim
Reference: 
PLoS Pathog 7(9): e1002197

Apicomplexans are obligate intracellular parasites that invade host cells by an active process leading to the formation of a non-fusogenic parasitophorous vacuole (PV) where the parasite replicates within the host cell.

Medical Condition: 

Male gametocyte fecundity and sex ratio of a malaria parasite, Plasmodium mexicanum

August 24, 2011 - 14:07 -- Kabogo Ndegwa
Author(s): 
A. T. Neal
Reference: 
Parasitology, Volume 138, Issue 10, September 2011, pp 1203 – 1210

Evolutionary theory predicts that the sex ratio of Plasmodium gametocytes will be determined by the number of gametes produced per male gametocyte (male fecundity), parasite clonal diversity and any factor that reduces male gametes' ability to find and combine with female gametes.

Medical Condition: 

Potent antimalarial 4-pyridones with improved physico-chemical properties

August 24, 2011 - 10:07 -- Kabogo Ndegwa
Author(s): 
José M. Bueno, Pilar Manzano, Domingo Gargallo-Viola, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 18, 15 September 2011, Pages 5214-5218

Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III).

Medical Condition: 
Medical Treatment: 

Open Access | Real-time PCR detection of Plasmodium directly from whole blood and filter paper samples

August 24, 2011 - 09:27 -- Kabogo Ndegwa
Author(s): 
Taylor BJ, Martin KA, Arango E, Agudelo OM, Maestre A, Yanow SK
Reference: 
Malaria Journal 2011, 10:244 (19 August 2011)

The methodology described facilitates high-throughput testing of blood samples collected in the field by fluorescence-based real-time PCR.

Medical Condition: 
Medical Treatment: 

Characterization of a new phosphatase from Plasmodium

August 16, 2011 - 12:18 -- Patrick Sampao
Author(s): 
Tanya Hills, Anubhav Srivastava, Kodjo Ayi, Amy K. Wernimont, Kevin Kain, Andrew P. Waters, Raymond Hui, Juan C. Pizarro
Reference: 
Molecular and Biochemical Parasitology, Volume 179, Issue 2, October 2011, Pages 69-79

We have determined the crystal structures of one of the P. falciparum's PGMases (PfPGM2) and a functionally distinct phosphoglycerate mutase from Cryptosporidium parvum, a related apicomplexan parasite.

Medical Condition: 

Open Access | Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion

August 11, 2011 - 07:34 -- Kabogo Ndegwa
Author(s): 
Prakash Srinivasan, Wandy L. Beatty, Ababacar Diouf, Raul Herrera, Xavier Ambroggio, J. Kathleen Moch, Jessica S. Tyler, David L. Narum, Susan K. Pierce, John C. Boothroyd, J. David Haynes, and Louis H. Miller
Reference: 
PNAS August 9, 2011 vol. 108 no. 32 13275-13280

The commitment of Plasmodium merozoites to invade red blood cells (RBCs) is marked by the formation of a junction between the merozoite and the RBC and the coordinated induction of the parasitophorous vacuole.

Medical Condition: 

Open Access | From the Cover: Rerooting the evolutionary tree of malaria parasites

August 11, 2011 - 07:31 -- Kabogo Ndegwa
Author(s): 
Diana C. Outlaw and Robert E. Ricklefs
Reference: 
PNAS August 9, 2011 vol. 108 no. 32 13183-13187

Malaria parasites (Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates.

Medical Condition: 

Open Access | Opportunities for improving pLDH-based malaria diagnostic tests

August 3, 2011 - 09:32 -- Kabogo Ndegwa
Author(s): 
Piper RC, Buchannan I, Choi YH, Makler MT
Reference: 
Malaria Journal 2011, 10:213 (1 August 2011)

These data emphasize that using different anti-pLDH antibody combinations offers a tractable way to optimize immunochromatographic pLDH tests.

Medical Condition: 
Medical Treatment: 

Open Access | Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

August 3, 2011 - 06:50 -- Kabogo Ndegwa
Author(s): 
Dow GS, Gettayacamin M, Hansukjariya P, Imerbsin R, Komcharoen S, Sattabongkot J, Kyle D, Milhous W, Cozens S, Kenworthy D, Miller A, Veazey J, Ohrt C
Reference: 
Malaria Journal 2011, 10:212 (29 July 2011)

Ten-fold lower clinical doses of tafenoquine than used in prior studies may be effective against P. vivax hypnozoites if the drug is deployed in combination with effective blood-schizonticidal drugs.

Medical Condition: 
Medical Treatment: 

Pages

Subscribe to RSS - Plasmodium