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CLOSED: Job: Postdoctoral Research Associate (Fellowship in Parasitology)

December 8, 2011 - 17:41 -- Ingeborg van Schayk


Organisation: Imperial College London, Division of Cell & Molecular Biology, Faculty of Natural Sciences, UK

Salary: £31,300 – £33,920 per annum

Closing date: 9 January 2012 (midnight GMT)


Open Access | Malaria: Origin of the Term ‘‘Hypnozoite’’

November 24, 2011 - 11:13 -- Ingeborg van Schayk
Miles B. Markus
Journal of the History of Biology (2011) 44:781–786

Hypnozoites are dormant forms in the life cycles of certain parasitic protozoa that belong to the Phylum Apicomplexa (Sporozoa) and are best known for their probable association with latency and relapse in human malarial infections caused by Plasmodium ovale and P. vivax. 

Open Access | Review: Regulating the Adaptive Immune Response to Blood-Stage Malaria: Role of Dendritic Cells and CD4+Foxp3+ Regulatory T Cells

November 22, 2011 - 14:42 -- Patrick Sampao
Mary M Stevenson, Rebecca Ing, Floriana Berretta, Jenny Miu
Int J Biol Sci 2011; 7:1311-1322

MalariaWorldHere, we review recent findings from our laboratory and others in experimental models of malaria in mice and in Plasmodium-infected humans on the roles of DC and natural regulatory T cells in regulating adaptive immunity to blood-stage malaria.

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Review: High resolution 3D perspective of Plasmodium biology: advancing into a new era

November 21, 2011 - 13:09 -- Patrick Sampao
Shiri Eshar, Noa Dahan-Pasternak, Allon Weiner, Ron Dzikowski
Trends in Parasitology, Volume 27, Issue 12, December 2011, Pages 548-554

MalariaWorldHere we bring together recent work on host cell invasion, hemoglobin uptake, protein export and nuclear dynamics.

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Review: Targeting Plasmodium liver stages: better late than never

November 16, 2011 - 09:22 -- Patrick Sampao
Steffen Borrmann, Kai Matuschewski
Trends in Molecular Medicine, Volume 17, Issue 9, September 2011, Pages 527-536

MalariaWorldHere, we review the basis, evidence and targets for whole-cell-based vaccination strategies against the liver stage bottleneck in Plasmodium infections and discuss preclinical and clinical research opportunities.

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CLOSED: Job: Post-Doctoral Position to study the effect of low power microwaves on Plasmodium falciparum

October 13, 2011 - 19:06 -- Ingeborg van Schayk
A post-doctoral position is available in the Dept. of Medicine, Penn State Univ. College of Medicine (USA) to work on a new research effort sponsored by the Bill and Melinda Gates Foundation.

Open Access | From the Cover: Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

October 12, 2011 - 07:31 -- Kabogo Ndegwa
Anil K. Ghosh, Isabelle Coppens, Henrik Gårdsvoll, Michael Ploug, and Marcelo Jacobs-Lorena
PNAS October 11, 2011 vol. 108 no. 41 17153-17158

MalariaWorldThe results support the hypothesis that enolase on the surface of Plasmodium ookinetes plays a dual role in midgut invasion: by acting as a ligand that interacts with the midgut epithelium and, further, by capturing plasminogen, whose conversion to active plasmin promotes the invasion process.

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Open Access | Early detection of malaria foci for targeted interventions in endemic southern Zambia

September 21, 2011 - 11:47 -- Kabogo Ndegwa
Ryan G Davis, Aniset Kamanga, Carlos Castillo-Salgado, Nnenna Chime, Sungano Mharakurwa, Clive Shiff
Malaria Journal 2011, 10:260 (12 September 2011)

The inconsistent sensitivity of the zonal threshold levels impugns the reliability of the alert system.

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Open Access | An Exhaustive, Non-Euclidean, Non-Parametric Data Mining Tool for Unraveling the Complexity of Biological Systems – Novel Insights into Malaria

September 21, 2011 - 07:14 -- Kabogo Ndegwa
Cheikh Loucoubar, Richard Paul, Jean-François Bureau, et al.
PLoS ONE 6(9): e24085

Complex, high-dimensional data sets pose significant analytical challenges in the post-genomic era. Such data sets are not exclusive to genetic analyses and are also pertinent to epidemiology.

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Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

September 21, 2011 - 06:27 -- Kabogo Ndegwa
Sofia Borges, Pedro Cravo, Alison Creasey, Richard Fawcett, Katarzyna Modrzynska, Louise Rodrigues, Axel Martinelli, and Paul Hunt
Antimicrobial Agents and Chemotherapy, October 2011,p. 4858-4865, Vol. 55, No. 10

Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs).

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