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Plasmodium

Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers

February 9, 2012 - 15:35 -- Kabogo Ndegwa
Author(s): 
Stephen T. McCracken, Marcel Kaiser, Helena I. Boshoff, Peter D.W. Boyd, Brent R. Copp
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 4, 15 February 2012, Pages 1482–1493

MalariaWorldPrevious studies have identified the 3,6-dialkyl-4-hydroxy-pyran-2-one marine microbial metabolites pseudopyronines A and B to be modest growth inhibitors of Mycobacterium tuberculosis and a range of tropical diseases including Plasmodium falciparum and Leishmania donovani.

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Open Access | The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology

February 8, 2012 - 08:24 -- Kabogo Ndegwa
Author(s): 
Julius Clemence R. Hafalla, Carla Claser, Kevin N. Couper, Georges Emile Grau, Laurent Renia, J. Brian de Souza, Eleanor M. Riley
Reference: 
PLoS Pathog 8(2): e1002504

MalariaWorldThe balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections.

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Assembly of the Eukaryotic PLP-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme

January 27, 2012 - 12:16 -- Patrick Sampao
Author(s): 
Gabriela Guédez, Katharina Hipp, Volker Windeisen, Bianca Derrer, Martin Gengenbacher, Bettina Böttcher, Irmgard Sinning, Barbara Kappes, Ivo Tews
Reference: 
Structure, Volume 20, Issue 1, 11 January 2012, Pages 172–184

MalariaWorldThe EM analysis shown here reveals a random association pattern of up to 12 Pdx2 glutaminase subunits to the dodecameric Pdx1 core complex.

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Reduced Impact of Pyrimethamine Drug Pressure on Plasmodium malariae Dihydrofolate Reductase Gene

January 24, 2012 - 13:00 -- Kabogo Ndegwa
Author(s): 
Nimol Khim, Saorin Kim, Didier Ménard, et al.
Reference: 
Antimicrob. Agents Chemother. February 2012 vol. 56 no. 2 863-868

MalariaWorldMolecular investigations performed following the emergence of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum have allowed the identification of the dihydrofolate reductase (DHFR) enzyme as the target of pyrimethamine.

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Endoplasmic Reticulum PI(3)P Lipid Binding Targets Malaria Proteins to the Host Cell

January 24, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Souvik Bhattacharjee, Robert V. Stahelin, Kaye D. Speicher, David W. Speicher, Kasturi Haldar
Reference: 
Cell, Volume 148, Issues 1–2, 20 January 2012, Pages 201–212

MalariaWorldHundreds of effector proteins of the human malaria parasite Plasmodium falciparum constitute a “secretome” carrying a host-targeting (HT) signal, which predicts their export from the intracellular pathogen into the surrounding erythrocyte.

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IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

January 24, 2012 - 06:55 -- Kabogo Ndegwa
Author(s): 
Ana Paula Freitas do Rosário, Tracey Lamb, Philip Spence, Robin Stephens, Agathe Lang, Axel Roers, Werner Muller, Anne O’Garra, and Jean Langhorne
Reference: 
The Journal of Immunology February 1, 2012 vol. 188 no. 3 1178-1190

MalariaWorldInfection with the malaria parasite, Plasmodium, is characterized by excessive inflammation.

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Open Access | Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

January 17, 2012 - 06:50 -- Kabogo Ndegwa
Author(s): 
Carina S. S. Gomes-Santos, Maurice A. Itoe, Maria M. Mota, et al.
Reference: 
PLoS ONE 7(1): e29408

MalariaWorldPlasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole.

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Antiparasitic drugs: Two-pronged tactics for malaria control

January 4, 2012 - 14:42 -- Kabogo Ndegwa
Author(s): 
Peter Kirkpatrick
Reference: 
Nature Reviews Drug Discovery 11, 24 (January 2012)

MalariaWorldMost existing and investigational drugs for malaria are targeted at the stages of the Plasmodium spp. parasite life cycle in red blood cells, which underlie the disease manifestations.

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Open Access | Engineered Anopheles Immunity to Plasmodium Infection

December 28, 2011 - 06:58 -- Kabogo Ndegwa
Author(s): 
Yuemei Dong, Suchismita Das, Chris Cirimotich, Jayme A. Souza-Neto, Kyle J. McLean, George Dimopoulos
Reference: 
PLoS Pathog 7(12): e1002458

MalariaWorldA causative agent of human malaria, Plasmodium falciparum, is transmitted by Anopheles mosquitoes.

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Open Access | Relatively Low Prevalence of Peripheral and Placental Plasmodium Infection at Delivery in Bangui, Central African Republic

December 23, 2011 - 12:45 -- Patrick Sampao
Author(s): 
Alexandre Manirakiza, Eugène Serdouma, Djibrine Djalle, Georges Soula, Remi Laganier, Nestor Madji, Methode Moyen, Alain Le Faou, and Jean Delmont
Reference: 
Journal of Tropical Medicine, Volume 2011 (2011)

MalariaWorldThe aim of this study was to estimate the prevalence of malaria among women giving birth in Bangui.

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