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Plasmodium

NOT Open Access | The evolution of metabolic enzymes in Plasmodium and trypanosomatids as compared to Saccharomyces and Schizosaccharomyces

May 23, 2012 - 09:54 -- Patrick Sampao
Author(s): 
Peter M. Palenchar, Jennifer B. Palenchar
Reference: 
Molecular and Biochemical Parasitology, Volume 184, Issue 1, July 2012, Pages 13-19

MalariaWorldHerein, we have determined Ka values, which are a measure of the non-synonymous substitution rate, and used them to examine the differences between the evolution of genes in T. brucei, P. falciparum, S. cerevisiae, and Schizosaccharomyces pombe.

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Review: Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach

May 11, 2012 - 13:13 -- Patrick Sampao
Author(s): 
Bharath Balu
Reference: 
Journal of Tropical Medicine, Volume 2012 (2012)

MalariaWorldFurther improvements to the mutagenesis technique and the design of novel genetic screens should lead us to some exciting discoveries about the critical weaknesses of Plasmodium, and greatly aid in the development of new disease intervention strategies.

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Open Access | Performance of a malaria microscopy image analysis slide reading device

May 9, 2012 - 15:10 -- Patrick Sampao
Author(s): 
Prescott WR, Jordan RG, Grobusch MP, Chinchilli VM, Kleinschmidt I, Borovsky J, Plaskow M, Torres M, Mico M, Schwabe C
Reference: 
Malaria Journal 2012, 11:155 (6 May 2012)

MalariaWorldReported here is an evaluation of a diagnostic system (a "device" consisting of a microscope, a scanner, and a computer algorithm) that evaluates scanned images of standard Giemsa-stained slides and reports species and parasitaemia.

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Open Access | Investigations on anopheline mosquitoes close to the nest sites of chimpanzees subject to malaria infection in Ugandan Highlands

April 19, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Krief S, Levrero F, Krief J, Thanapongpichat S, Imwong M, Snounou G, Kasenene JM, Cibot M, Gantier J
Reference: 
Malaria Journal 2012, 11:116 (17 April 2012)

MalariaWorldThe mosquito catches yielded a total of 309 female Anopheles specimens, the only known vectors of malaria parasites of mammalians.

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Open Access | The biology of sexual development of Plasmodium: The design and implementation of transmission-blocking strategies

March 22, 2012 - 12:59 -- Kabogo Ndegwa
Author(s): 
Sinden RE, Carter R, Drakeley C, Leroy D
Reference: 
Malaria Journal 2012, 11:70 (16 March 2012)

MalariaWorldA meeting to discuss the latest developments in the biology of sexual development of Plasmodium and transmission-control was held April 5-6, 2011, in Bethesda, MD.

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From the Cover: Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

March 14, 2012 - 14:20 -- Kabogo Ndegwa
Author(s): 
Joo Hwan No, Fernando de Macedo Dossin, Eric Oldfield, et al.
Reference: 
PNAS March 13, 2012 vol. 109 no. 11 4058-4063

MalariaWorldWe report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors.

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Open Access | PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

March 8, 2012 - 06:54 -- Kabogo Ndegwa
Author(s): 
Min Zhang, Satish Mishra, Ramanavelan Sakthivel, Margarito Rojas, Ravikant Ranjan, William J. Sullivan, Jr, Beatriz M. A. Fontoura, Robert Ménard, Thomas E. Dever, and Victor Nussenzweig
Reference: 
PNAS March 6, 2012 vol. 109 no. 10 3956-3961

MalariaWorldIn response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis.

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Open Access | The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

February 23, 2012 - 15:53 -- Patrick Sampao
Author(s): 
Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin, Elizabeth A. Winzeler, Robert E. Sinden, Didier Leroy
Reference: 
PLoS Medicine ,February 2012 Volume 9 Issue 2 e1001169

MalariaWorldThis study might reveal the potential of life-cycle–wide analyses of drugs for other pathogens with complex life cycles.

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A PIP Gets the Plasmodium Protein Export Pathway Going

February 21, 2012 - 07:02 -- Kabogo Ndegwa
Author(s): 
Rays H.Y. Jiang, Matthias Marti
Reference: 
Cell Host & Microbe, Volume 11, Issue 2, 16 February 2012, Pages 99–100

MalariaWorldSurvival of blood stage malaria parasites requires extensive host cell remodeling, which is facilitated by secretion of parasite proteins via a dedicated protein export pathway.

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