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Plasmodium

Open Access | Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

June 22, 2010 - 10:36 -- Kabogo Ndegwa
Author(s): 
Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, Niangaly A, Duan J, Ellis RD, Miller LH, Su X, Plowe CV, Doumbo OK
Reference: 
Malaria Journal 2010, 9:175 (21 June 2010)

This Phase 2 trial of a bivalent AMA1 malaria vaccine found no evidence of vaccine selection or strain-specific efficacy, suggesting that the extreme genetic diversity of AMA1 did not account for failure of the vaccine to provide protection.

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Open Access | Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum

June 22, 2010 - 07:16 -- Kabogo Ndegwa
Author(s): 
Carmenza Spadafora, Gordon A. Awandare, Karen M. Kopydlowski, Jozsef Czege, J. Kathleen Moch, Robert W. Finberg, George C. Tsokos, José A. Stoute
Reference: 
PLoS Pathog 6(6): e1000968

Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood. P. falciparum depends heavily on sialic acid present on glycophorins to invade erythrocytes.

Open Access | Model variations in predicting incidence of Plasmodium falciparum malaria using 1998-2007 morbidity and meteorological data from south Ethiopia

June 18, 2010 - 12:30 -- Patrick Sampao
Author(s): 
Loha E, Lindtjorn B
Reference: 
Malaria Journal 2010, 9:166 (16 June 2010)

This study describes P. falciparum malaria incidence models linked with meteorological data. Variability in the models was principally attributed to regional differences, and a single model was not found that fits all locations.

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Open Access | New synchronization method for Plasmodium falciparum

June 18, 2010 - 10:10 -- Patrick Sampao
Author(s): 
Ranford-Cartwright LC, Sinha A, Humphreys GS, Mwangi JM
Reference: 
Malaria Journal 2010, 9:170 (17 June 2010)

The new method for parasite synchronization results in highly synchronized populations of parasites, which will be useful for studies of the parasite asexual cell cycle.

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Experimentsl Therapeutics: Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth

June 18, 2010 - 09:41 -- Kabogo Ndegwa
Author(s): 
Agam Prasad Singh, Yonghui Zhang, Joo-Hwan No, Roberto Docampo, Victor Nussenzweig, and Eric Oldfield
Reference: 
Antimicrobial Agents and Chemotherapy, July 2010, p. 2987-2993, Vol. 54, No. 7

Nitrogen-containing bisphosphonates, drugs used to treat bone resorption diseases, also have activity against a broad range of protists, including blood-stage Plasmodium spp. Here, we show that new-generation "lipophilic" bisphosphonates designed as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages, with a high (>100) therapeutic index.

Expression, purification and characterization of allelic variants of MSP-142 from Indian Plasmodium falciparum isolates

June 14, 2010 - 12:57 -- Patrick Sampao
Author(s): 
P.V. Lalitha, S. Biswas, C.R. Pillai, R.K. Seth, R.K. Saxena
Reference: 
Vaccine, Volume 28, Issue 29, 23 June 2010, Pages 4661-4667

The C-terminal 19 and 42 kDa fragments of Plasmodium falciparum merozoite surface protein 1 (MSP-1) have shown to be protective in animals against lethal parasite challenge.

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Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline

June 14, 2010 - 12:48 -- Kabogo Ndegwa
Author(s): 
Anna Sparatore, Nicoletta Basilico, Manolo Casagrande, Silvia Parapini, Donatella Taramelli, Reto Brun, Sergio Wittlin, Fabio Sparatore
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 13, 1 July 2008, Pages 3737-3740

Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a Plasmodium berghei mouse model of infection.

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Open Access | Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum

June 11, 2010 - 08:35 -- Patrick Sampao
Author(s): 
Salgueiro P, Vicente JL, Ferreira C, Teofilo V, Galvao A, do Rosario VE, Cravo P, Pinto J
Reference: 
BMC Infectious Diseases 2010, 10:163 (9 June 2010)

This study provides additional evidence for the crucial role of gene flow and drug selective pressures in the rapid spread of SP resistance in P. falciparum populations, from only a few mutation events giving rise to resistance-associated mutants.

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Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP142

June 10, 2010 - 08:14 -- Patrick Sampao
Author(s): 
Richard Weiss, Maximilian Gabler, Thomas Jacobs, Tim-Wolf Gilberger, Josef Thalhamer, Sandra Scheiblhofer
Reference: 
Vaccine, Volume 28, Issue 28, 17 June 2010, Pages 4515-4522

In this work, C3d exerted differential effects on humoral immune responses after gene gun immunization of mice with plasmids encoding the malaria blood stage antigen MSP142 depending on the nature of the protein Plasmodium falciparum vs. Plasmodium berghei MSP), the localization of the C3d moiety (C-terminal vs. N-terminal), and the presence of putative N-glycosylation sites.

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Short Communication: Plasmodium vivax in the Democratic Republic of East Timor: Parasite prevalence and antifolate resistance-associated mutations

June 9, 2010 - 08:22 -- Kabogo Ndegwa
Author(s): 
Afonso de Almeida, Virgílio E. do Rosário, Gisela Henriques, Ana Paula Arez, Pedro Cravo
Reference: 
Acta Tropica, Volume 115, Issue 3, September 2010, Pages 288-292

In the Democratic Republic of East Timor, Plasmodium falciparum and Plasmodium vivax malaria coexist, but limited information is available about the latter species. Consequently, the prevalence of P. vivax and of its corresponding antifolate resistance-associated mutations in the pvdhfr and pvdhps genes was assessed here.

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