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Plasmodium

Open Access | An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes

July 13, 2010 - 13:22 -- Kabogo Ndegwa
Author(s): 
Ghosh AK, Dinglasan RR, Ikadai H, Jacobs-Lorena M
Reference: 
Malaria Journal 2010, 9:194 (8 July 2010)

This simple and practical improvement over the prevailing methodology will facilitate the investigation of how this important human malaria parasite initiates its development in the mosquito and will contribute to the understanding of its transmission biology.

Open Access | Malaria rapid diagnostic tests: Plasmodium falciparum infections with high parasite densities may generate false positive Plasmodium vivax pLDH lines

July 12, 2010 - 14:50 -- Kabogo Ndegwa
Author(s): 
Maltha J, Gillet P, Cnops L, van den Ende J, van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2010, 9:198 (10 July 2010)

False positive Pv-pLDH lines in P. falciparum samples with high parasite density occurred in 6/9 P. vivax-specific RDTs. This is of concern as P. falciparum and P. vivax are co-circulating in many regions. The diagnosis of life-threatening P. falciparum malaria may be missed (two-band Pv-pLDH RDT), or the patient may be treated incorrectly with primaquine (three- or four-band RDTs).

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Open Access | Malaria parasite genome scan: insights into antimalarial resistance

July 12, 2010 - 14:29 -- Kabogo Ndegwa
Author(s): 
Bhavna Gupta, Gauri Awasthi and Aparup Das
Reference: 
Parasitology Research, Volume 107, Number 2 / July, 2010

Genome scan and genotype-phenotype association study offer excellent opportunities to unearth drug/vaccine targets in human pathogens including malaria parasites.

Intravenous Ibuprofen (IV-ibuprofen) Controls Fever Effectively in Adults with Acute Uncomplicated Plasmodium falciparum Malaria but Prolongs Parasitemia

July 2, 2010 - 13:39 -- Patrick Sampao
Author(s): 
Srivicha K., Noppadon T., et al.
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 51 - 55.

Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine.

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Indigenous Plasmodium ovale Malaria in Bangladesh

July 2, 2010 - 13:11 -- Patrick Sampao
Author(s): 
Hans-Peter F., Peter S., et al.
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 75 - 78.

We used a genus- and species-specific nested polymerase chain reaction, targeting highly conserved regions of the small subunit ribosomal RNA (SSU rRNA) gene, to investigate the presence of malaria parasites in a total number of 379 patient samples in a survey of patients with febrile illnesses in the Chittagong Hill Tracts in Southeastern Bangladesh.

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Open Access | Disorders of Iron Metabolism: Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

July 1, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Reference: 
Haematologica, July 2010; 95: 1068 - 1074.

Asymptomatic malarial parasitemia is associated with increased hepcidin concentrations and anemia, in the absence of a manifest acute phase response.

Prevalence of 5′ insertion mutants and analysis of single nucleotide polymorphism in the erythrocyte binding-like 1 (ebl-1) gene in Kenyan Plasmodium falciparum field isolates

June 30, 2010 - 15:11 -- Patrick Sampao
Author(s): 
Elijah K. Githui, David S. Peterson, Rashid A. Aman, Abdirahman I. Abdi
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 6, August 2010, Pages 833-838

This study is now extended to include field isolates collected from sites within Kenya. DNA isolated from blood samples of infected patients was utilized to amplify the region I sequence of ebl-1 gene in order to investigate polymorphism in the region immediately adjacent to the 5′ cysteine-rich domains, and to determine the prevalence of an insertion mutant that effectively knocks out the gene.

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Open Access | Cognitive Dysfunction Is Sustained after Rescue Therapy in Experimental Cerebral Malaria, and Is Reduced by Additive Antioxidant Therapy

June 29, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
Patricia A. Reis, Clarissa M. Comim, Hugo C. Castro-Faria-Neto, .et al
Reference: 
PLoS Pathog 6(6): e1000963

Neurological impairments are frequently detected in children surviving cerebral malaria (CM), the most severe neurological complication of infection with Plasmodium falciparum.

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Report: New Stages in the Program of Malaria Parasite Egress Imaged in Normal and Sickle Erythrocytes

June 24, 2010 - 08:28 -- Kabogo Ndegwa
Author(s): 
Svetlana Glushakova, Glen Humphrey, Evgenia Leikina, Amanda Balaban, Jeffrey Miller, Joshua Zimmerberg
Reference: 
Current Biology, Volume 20, Issue 12, 22 June 2010, Pages 1117-1121

The apicomplexan parasite Plasmodium falciparum causes malignant malaria. The mechanism of parasite egress from infected erythrocytes that disseminate parasites in the host at the end of each asexual cycle is unknown [1].

Prophylactic and curative activities of extracts from Warburgia ugandensis Sprague (Canellaceae) and Zanthoxylum usambarense (Engl.) Kokwaro (Rutaceae) against Plasmodium knowlesi and Plasmodium berghei

June 23, 2010 - 08:50 -- Patrick Sampao
Author(s): 
P.S. Were, P. Kinyanjui, M.M. Gicheru, E. Mwangi, H.S. Ozwara
Reference: 
Journal of Ethnopharmacology, Volume 130, Issue 1, 6 July 2010, Pages 158-162

This work reports the anti-plasmodial activities of Warburgia ugandensis and Zanthoxylum usambarense commonly used as phytomedicines against malaria by some Kenyan communities.

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