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Plasmodium

Open Access | Clinical Trials and Observations: High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

September 10, 2010 - 13:29 -- Kabogo Ndegwa
Author(s): 
Charlotte F. McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H. Opi, Carolyne Ndila, Antony Ngatia, John Anthony G. Scott, Kevin Marsh, and Thomas N. Williams
Reference: 
Blood, 9 September 2010, Vol. 116, No. 10, pp. 1663-1668.

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya.

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Open Access | A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting

September 9, 2010 - 12:43 -- Patrick Sampao
Author(s): 
Harris I, Sharrock WW, Bain LM, Gray K, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson M, Gatton ML, Shanks GD, Cheng Q
Reference: 
Malaria Journal 2010, 9:254 (7 September 2010)

During the survey, 9,491 blood samples were collected and examined by microscopy for Plasmodium species and density, with a subset also examined by polymerase chain reaction (PCR) and rapid diagnostic tests (RDTs).

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Minireview: Regulation of immunity to Plasmodium: Implications from mouse models for blood stage malaria vaccine design

September 8, 2010 - 08:46 -- Kabogo Ndegwa
Author(s): 
Andrew W. Taylor-Robinson
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 406-414

Malaria, a disease caused by the protozoan parasite Plasmodium, remains a serious healthcare problem in developing countries worldwide.

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Minireviews | Epigenetics in Plasmodium: What Do We Really Know?

August 9, 2010 - 08:03 -- Patrick Sampao
Author(s): 
Catherine J. Merrick and Manoj T. Duraisingh
Reference: 
Eukaryot. Cell, Aug 2010; 9: 1150 - 1158

This review will focus upon the challenge of understanding Plasmodium epigenetics in an integrated manner, in the human and insect hosts as well as the petri dish.

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Open Access | Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

July 29, 2010 - 11:46 -- Kabogo Ndegwa
Author(s): 
Marta C. Nunes, Mami Okada, Christine Scheidig-Benatar, Brian M. Cooke, Artur Scherf
Reference: 
PLoS ONE 5(7): e11747

Our results suggest that FIKK members phosphorylate different membrane skeleton proteins of the infected erythrocyte in a stage-specific manner, inducing alterations in the mechanical properties of the parasite-infected red blood cell.

Open Access | Buffer substitution in malaria rapid diagnostic tests causes false-positive results

July 26, 2010 - 14:16 -- Kabogo Ndegwa
Author(s): 
Gillet P, Mori M, Van den Ende J, Jacobs J
Reference: 
Malaria Journal 2010, 9:215 (22 July 2010)

Replacement of the RDT kit's dedicated buffer by saline, distilled water and tap water can cause false-positive test results.

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Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

July 19, 2010 - 08:42 -- Kabogo Ndegwa
Author(s): 
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
Reference: 
PLoS Pathog 6(7): e1000998

Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce sterilizing protection against malaria in both humans and rodents.

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Open Access | Anopheles Gambiae PRS1 Modulates Plasmodium Development at Both Midgut and Salivary Gland Steps

July 16, 2010 - 14:12 -- Kabogo Ndegwa
Author(s): 
Thomas Chertemps, Christian Mitri, Sylvie Perrot, Jean Sautereau, Jean-Claude Jacques, Isabelle Thiery, Catherine Bourgouin, Isabelle Rosinski-Chupin
Reference: 
PLoS ONE 5(7): e11538

While providing insights into potential functions of DM9 proteins, our results reveal that PRS1 likely contributes to fundamental interactions between Plasmodium and mosquito epithelia, which do not depend on the specific Anopheles/P. falciparum coevolutionary history.

Parasitology: Evaluation of a Loop-Mediated Isothermal Amplification Method as a Tool for Diagnosis of Infection by the Zoonotic Simian Malaria Parasite Plasmodium knowlesi

July 16, 2010 - 12:11 -- Patrick Sampao
Author(s): 
Hiroshi Iseki, Satoru Kawai, Nobuyuki Takahashi, Makoto Hirai, Kazuyuki Tanabe, Naoaki Yokoyama, and Ikuo Igarashi
Reference: 
J. Clin. Microbiol., Jul 2010; 48: 2509 - 2514

In the present study, we developed a LAMP method for the molecular diagnosis of Plasmodium knowlesi infection (PkLAMP) and evaluated its sensitivity, specificity, and clinical applicability.

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Open Access | CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives

July 15, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Boulton IC, Nwaka S, Bathurst I, Lanzer M, Taramelli D, Vial H, Doerig C, Chibale K, Ward SA
Reference: 
Malaria Journal 2010, 9:202 (13 July 2010)

Despite increasing efforts and support for anti-malarial drug R&D, globally anti-malarial drug discovery and development remains largely uncoordinated and fragmented.

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