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Plasmodium

Parasitology: Accurate and Sensitive Detection of Plasmodium Species in Humans by Use of the Dihydrofolate Reductase-Thymidylate Synthase Linker Region

October 1, 2010 - 10:03 -- Patrick Sampao
Author(s): 
Naowarat T., Mallika I., et al.
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3735 - 3737.

A nested-PCR protocol based on the linker region of the Plasmodium dihydrofolate reductase-thymidylate synthase gene (dhfr-ts) was developed.

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Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast

October 1, 2010 - 08:47 -- Patrick Sampao
Author(s): 
Lina T., Gaëtan C., et al.
Reference: 
Eukaryot. Cell, Oct 2010; 9: 1519 - 1530.

We hypothesize that these vesicles might be involved in transport processes, likely of proteins and lipids, toward the essential and peculiar parasite compartment, which is the apicoplast.

Open Access | Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial

September 22, 2010 - 14:07 -- Patrick Sampao
Author(s): 
Kirwan P, Jackson AL, Asaolu SO, Molloy SF, Abiona TC, Bruce MC, Ranford-Cartwright L, O'Neill SM, Holland CV
Reference: 
BMC Infectious Diseases 2010, 10:277 (21 September 2010)

A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months.

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Mechanisms of genetically-based resistance to malaria

September 21, 2010 - 07:03 -- Kabogo Ndegwa
Author(s): 
Carolina López, Carolina Saravia, Andromeda Gomez, Johan Hoebeke, Manuel A. Patarroyo
Reference: 
Gene, Volume 467, Issues 1-2, 1 November 2010, Pages 1-12

Malaria remains one of the most prevalent parasitoses worldwide. About 350 to 500 million febrile episodes are observed yearly in African children alone and more than 1 million people die because of malaria each year.

Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes

September 20, 2010 - 12:55 -- Kabogo Ndegwa
Author(s): 
Daniel E. Goldberg, Alan F. Cowman
Reference: 
Nature Reviews Microbiology 8, 617-621 (September 2010)

Malaria parasites live within erythrocytes in the host bloodstream and induce crucial changes to these cells. By so doing, they can obtain the nutrients that they require for growth and can effect the evasion and perturbation of host defences.

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Open Access | Neopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria

September 15, 2010 - 14:01 -- Kabogo Ndegwa
Author(s): 
Rene te Witt R, van Wolfswinkel ME, Petit PL, van Hellemond JJ, Koelewijn R, van Belkum A, van Genderen PJ
Reference: 
Malaria Journal 2010, 9:255 (14 September 2010)

Although the diagnostic value of neopterin and procalcitonin is limited, the high negative predictive value of both neopterin and procalcitonin may be helpful for a rapid exclusion of severe malaria disease on admission.

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Open Access | Long- and Short-Term Selective Forces on Malaria Parasite Genomes

September 13, 2010 - 13:03 -- Kabogo Ndegwa
Author(s): 
Sanne Nygaard, Alexander Braunstein, Daniel C. Jeffares,.et al
Reference: 
PLoS Genet 6(9): e1001099

Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ~23 Mb genomes encoding ~5200 protein-coding genes.

Open Access | SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

September 13, 2010 - 12:51 -- Kabogo Ndegwa
Author(s): 
Abdirahman Abdi, Sylvain Eschenlauer, Luc Reininger & Christian Doerig
Reference: 
Cellular and Molecular Life Sciences Volume 67, Number 19, 3355-3369

Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases.

Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells

September 10, 2010 - 14:35 -- Patrick Sampao
Author(s): 
Martin M., Rebecca A., et al.
Reference: 
Cellular Microbiology, Volume 12, Issue 10, pages 1446–1462, October 2010

This study establishes a new system to investigate PfEMP1 transport and demonstrates that the PfEMP1 semi-conserved head structure is under selection for protein transport, in addition to its known roles in adhesion.

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