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Plasmodium

Partnering Parasites: Evidence of Synergism between Heavy Schistosoma haematobium and Plasmodium Species Infections in Kenyan Children

August 2, 2012 - 07:01 -- Kabogo Ndegwa
Author(s): 
Lia S. Florey, Charles H. King, Melissa K. Van Dyke, Eric M. Muchiri, Peter L. Mungai, Peter A. Zimmerman, Mark L. Wilson
Reference: 
PLoS Negl Trop Dis 6(7): e1723.

MalariaWorldChildren in this community are more likely to be infected with multiple parasites than are adults and should therefore be targeted for prevention and control interventions.

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NOT Open Access | Fighting malaria with engineered symbiotic bacteria from vector mosquitoes

August 2, 2012 - 06:58 -- Kabogo Ndegwa
Author(s): 
Sibao Wang, Anil K. Ghosh, Nicholas Bongio, Kevin A. Stebbings, David J. Lampe, and Marcelo Jacobs-Lorena
Reference: 
PNAS July 31, 2012 vol. 109 no. 31 12734-12739

MalariaWorldThe most vulnerable stages of Plasmodium development occur in the lumen of the mosquito midgut, a compartment shared with symbiotic bacteria.

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Diversity of anopheline species and their Plasmodium infection status in rural bandarban, Bangladesh

August 1, 2012 - 12:53 -- Patrick Sampao
Author(s): 
Alam MS, Chakma S, Khan WA, Glass GE, Mohon AN, Elahi R, Norris LC, Podder MP, Ahmed S, Haque R, Sack DA, Sullivan DJ, Norris DE
Reference: 
Parasites & Vectors 2012, 5:150 (27 July 2012)

MalariaWorldThe findings of this study suggest that even in the presence of an insecticide impregnated bed-net intervention, a number of Anopheles species still play a role in the transmission of malaria.

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Shedding of TRAP by a Rhomboid Protease from the Malaria Sporozoite Surface Is Essential for Gliding Motility and Sporozoite Infectivity

July 31, 2012 - 06:58 -- Kabogo Ndegwa
Author(s): 
Ijeoma Ejigiri, Daniel R. T. Ragheb, Paco Pino, Alida Coppi, Brandy Lee Bennett, Dominique Soldati-Favre, Photini Sinnis
Reference: 
PLoS Pathog 8(7): e1002725

MalariaWorldPlasmodium sporozoites, the infective stage of the malaria parasite, move by gliding motility, a unique form of locomotion required for tissue migration and host cell invasion.

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Did the first Global Fund grant (2003-2006) contribute to malaria control and health system strengthening in Timor-Leste?

July 25, 2012 - 13:45 -- Kabogo Ndegwa
Author(s): 
Martins J, Zwi AB, Kelly PM
Reference: 
Malaria Journal 2012, 11:237 (23 July 2012)

MalariaWorldDespite limitations, the grant was implemented until the agreed closing date.

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Flow cytometric readout based on Mitotracker Red CMXRos staining of live asexual blood stage malarial parasites reliably assesses antibody dependent cellular inhibition

July 24, 2012 - 11:19 -- Kabogo Ndegwa
Author(s): 
Jogdand PS, Singh SK, Christiansen M, Dziegiel MH, Singh S, Theisen M
Reference: 
Malaria Journal 2012, 11:235 (20 July 2012)

MalariaWorldA flow cytometry method based on CMXRos staining for detection of live parasite populations has been optimized.

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Not Open Access | Generation of second messengers in Plasmodium

July 13, 2012 - 09:09 -- Patrick Sampao
Author(s): 
Alexandre Budu, Célia R.S. Garcia
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 787-795

MalariaWorldThe scope of this review is to discuss external stimuli in the parasite life cycle and the upstream machinery responsible for translating them into intracellular responses, focussing particularly on the calcium signalling pathway.

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Pharmacokinetics of Piperaquine in Pregnant Women in Sudan with Uncomplicated Plasmodium falciparum Malaria

July 4, 2012 - 13:12 -- Patrick Sampao
Author(s): 
Ishag Adam, Joel Tarning, Niklas Lindegardh, Hyder Mahgoub, Rose McGready and François Nosten
Reference: 
Am J Trop Med Hyg 2012 87:35-40

MalariaWorldThe overall pharmacokinetic properties of piperaquine in this study were consistent with previously published reports in non-pregnant patients.

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Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay

June 19, 2012 - 11:19 -- Kabogo Ndegwa
Author(s): 
Sopitthummakhun K, Thongpanchang C, Vilaivan T, Yuthavong Y, Chaiyen P, Leartsakulpanich U
Reference: 
Malaria Journal 2012, 11:194 (12 June 2012)

Auto-induction media offers a cost-effective method for the production of Plasmodium SHMTs and should be applicable for other Plasmodium enzymes.

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Not Open Access | Status of Plasmodium vivax malaria in the Republic of Korea, 2008–2009: decrease followed by resurgence

June 11, 2012 - 15:02 -- Patrick Sampao
Author(s): 
Joon-Sup Yeom, Gyo Jun, Jung-Yeon Kim, Won-Ja Lee, E-Hyun Shin, Kyu-Sik Chang, Ji-Hwan Bang, Sejoong Oh, Joon-Young Kang, Jae-Won Park
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, Issue 7, July 2012, Pages 429-436

MalariaWorldThe number of Plasmodium vivaxmalaria cases in the Republic of Korea (ROK) in 2008 was 1009, a 54.2% decrease on the previous year. It then resurged to 1317 cases in 2009 (30.5% increase on 2008).

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