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immune system

Update: Focusing on complement in the antiparasitic defense of mosquitoes

December 29, 2009 - 14:23 -- Patrick Sampao
Gloria Volohonskya, Stefanie Steinerta and Elena A. Levashina
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 1-3

Identification of the components of the mosquito complement system now provides new focus for studies on the activation and control of this pathway, whose manipulation is expected to block malaria transmission at the vector level.

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Review : Immunomodulation by phosphocholine—Biosynthesis, structures and immunological implications of parasitic PC-epitopes

December 10, 2009 - 09:46 -- Patrick Sampao
Julia Grabitzki, Günter Lochnit.
Molecular Immunology, Volume 47, Issues 2-3, December 2009, Pages 149-163

Phosphocholine (PC) as a small haptenic molecule present on antigens of parasites can provoke various effects on immune cells leading to immunomodulation of the host's immune system.

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Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria

December 3, 2009 - 09:22 -- Patrick Sampao
Julián F. Hillyer, Tania Y. Estévez-Lao
Developmental & Comparative Immunology, Volume 34, Issue 2, February 2010, Pages 141-149, doi:10.1016/j.dci.2009.08.014

Here, we characterized the temporal and spatial expression of the Anopheles gambiae nitric oxide synthase gene and explored the role nitric oxide plays in the antibacterial response in the mosquito hemocoel.

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