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merozoite

Comparative Immunogenicities of Full-Length Plasmodium falciparum Merozoite Surface Protein 3 and a 24-Kilodalton N-Terminal Fragment

August 3, 2011 - 09:28 -- Kabogo Ndegwa
Author(s): 
Maryam Imam, Yengkhom Sangeeta Devi, Akhilesh K. Verma, and Virander Singh Chauhan
Reference: 
Clinical and Vaccine Immunology, August 2011,p. 1221-1228, Vol. 18, No. 8

Recombinant Plasmodium falciparum merozoite surface protein 3 (PfMSP3F) and a 24-kDa fragment from its N terminus (MSP3N) that includes the essential conserved domain, which elicits the maximum antibody (Ab)-dependent cellular inhibition (ADCI), were expressed as soluble proteins in Escherichia coli. Both proteins were found to be stable in both soluble and lyophilized forms.

Open Access | The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP119)

July 26, 2011 - 13:16 -- Patrick Sampao
Author(s): 
Jianguo Shi, Richard S McIntosh, Richard J Pleass, et al.
Reference: 
BMC Biotechnology 2011, 11:77

To explore the mechanism(s) by which IgA may mediate a protective effect, we generated fully human IgA specific for the C-terminal 19-kDa region of Plasmodium falciparum merozoite surface protein 1 (PfMSP119), a major target of protective immune responses.

Open Access | Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

June 22, 2011 - 07:00 -- Kabogo Ndegwa
Author(s): 
Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T. Riglar, Anthony N. Hodder, Stuart A. Ralph, Jake Baum, Alan F. Cowman
Reference: 
PLoS Pathog 7(6): e1002075

Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand-receptor interactions.

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Open Access | Delineation of Stage Specific Expression of Plasmodium falciparum EBA-175 by Biologically Functional Region II Monoclonal Antibodies

April 27, 2011 - 11:13 -- Kabogo Ndegwa
Author(s): 
B. Kim Lee Sim, David L. Narum, Rana Chattopadhyay, Adriana Ahumada, J. David Haynes, Steven R. Fuhrmann, Jennifer N. Wingard, Hong Liang, J. Kathleen Moch, Stephen L. Hoffman
Reference: 
PLoS ONE 6(4): e18393

The role of the F1 and F2 domains in erythrocyte invasion and binding was elucidated with mAbs.

Malaria Immunoepidemiology in Low Transmission: Correlation of Infecting Genotype and Immune Response to Domains of Plasmodium falciparum Merozoite Surface Protein 3

April 23, 2011 - 08:47 -- Patrick Sampao
Author(s): 
Stephen J. Jordan, Ana L. Oliveira, Jean N. Hernandez, Robert A. Oster, Debasish Chattopadhyay, OraLee H. Branch, and Julian C. Rayner
Reference: 
Infect. Immun., May 2011; 79: 2070 - 2078.

Evidence for cross-reactive responses was much stronger when variants within one allele class were tested, which has implications for the rational development of genotype-transcending PfMSP3-based vaccines.

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Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)

March 2, 2011 - 08:29 -- Kabogo Ndegwa
Author(s): 
Hernando Curtidor, Liliana C. Patiño, Gabriela Arévalo-Pinzón, Manuel E. Patarroyo, Manuel A. Patarroyo
Reference: 
Gene, Volume 474, Issues 1-2, 15 March 2011, Pages 22-28

Gathering knowledge about the proteins involved in erythrocyte invasion by Plasmodium merozoites is the starting point for developing new strategies to control malarial disease.

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Short Communication: Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

March 1, 2011 - 08:01 -- Patrick Sampao
Author(s): 
Diego Garzón-Ospina, Liza Romero-Murillo, Luisa F. Tobón, Manuel A. Patarroyo
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 528-531

Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity.

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Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

January 24, 2011 - 10:09 -- Kabogo Ndegwa
Author(s): 
David T. Riglar, Dave Richard, Jake Baum, et al.
Reference: 
Cell Host & Microbe, Volume 9, Issue 1, 20 January 2011, Pages 9-20

Erythrocyte invasion by the merozoite is an obligatory stage in Plasmodium parasite infection and essential to malaria disease progression.

Open Access | Oral Presentation: A library of functional recombinant Plasmodium falciparum merozoite surface proteins

November 5, 2010 - 11:29 -- Patrick Sampao
Author(s): 
Cecile Crosnier, Madushi Wanaguru, Brian McDade, Julian Rayner, Gavin J Wright
Reference: 
Malaria Journal 2010, 9(Suppl 2):O8 (20 October 2010)

All the clinical symptoms of malaria result from the invasion of human erythrocytes by the parasite's merozoites.

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