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2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections

October 18, 2010 - 09:25 -- Patrick Sampao
Deniz T., David S., et al.
Bioorganic & Medicinal Chemistry, Volume 18, Issue 21, 1 November 2010, Pages 7475-7485

This is the first study to indicate therapeutic potential of HDAs against various parasitic protozoa. It also points out that the malarial liver stage growth inhibitory effect of the 2-HDA may be promoted via PfFAS-II enzymes.

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