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Open Access | Inhibition of Plasmodium falciparum Field Isolates-Mediated Endothelial Cell Apoptosis by Fasudil: Therapeutic Implications for Severe Malaria

October 18, 2010 - 09:12 -- Patrick Sampao
Author(s): 
Estelle S., Ulrick B., et al.
Reference: 
PLoS ONE 5(10): e13221.

We therefore assessed herein whether Fasudil would have a similar efficiency on P. falciparum taken directly from malaria patients using contact and non-contact experiments. Seven (23.3%) of 30 PRBC preparations from different patients were apoptogenic, four (13.3%) acting by cytoadherence and three (10%) via soluble factors.

Technology: 
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