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Open Access | Biochemical Properties of a Novel Cysteine Protease of Plasmodium vivax, Vivapain-4

October 16, 2010 - 08:38 -- Kabogo Ndegwa
Byoung-Kuk Na, Young-An Bae, Young-Gun Zo, Youngchool Choe, Seon-Hee Kim, Prashant V. Desai, Mitchell A. Avery, Charles S. Craik, Tong-Soo Kim, Philip J. Rosenthal, Yoon Kong
PLoS Negl Trop Dis 4(10): e849

VX-4 demonstrates pH-dependent substrate switching, which might offer an efficient mechanism for the specific cleavage of different substrates in different intracellular environments. VX-4 might function as a hemoglobinase in the acidic parasite food vacuole, a maturase of P. vivax plasmepsin 4 at neutral or acidic pH, and a cytoskeleton-degrading protease in the neutral erythrocyte cytosol.

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