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chloroquine-resistant (K1)

Open Access | Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro (pages 1468–1472)

September 30, 2010 - 07:31 -- Kabogo Ndegwa
Author(s): 
Abraham Abebe Wube, Franz Bucar, Simon Gibbons, Kaleab Asres, Lauren Rattray and Simon L. Croft
Reference: 
Phytotherapy Research, Volume 24, Issue 10, pages 1468–1472, October 2010

The extracts and 12 sesquiterpenes obtained from the East African medicinal plant Warburgia ugandensis Sprague (Canellaceae) were assessed for their antiplasmodial activity against the chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum and antitrypanosomal activity against Trypanosoma brucei rhodesiense.

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