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plasmodium flaciparum

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

September 23, 2010 - 09:10 -- Kabogo Ndegwa
Kung Ban, Sandra Duffy, Yelena Khakham, Vicky M. Avery, Andrew Hughes, Oliver Montagnat, Kasiram Katneni, Eileen Ryan, Jonathan B. Baell
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 20, 15 October 2010, Pages 6024-6029

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells.

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