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Plasmodium vivax

Measurement of naturally acquired humoral immune responses against the C-terminal region of the Plasmodium vivax MSP1 protein using protein arrays

October 26, 2011 - 06:46 -- Kabogo Ndegwa
Author(s): 
Jun-Hu Chen, Yue Wang, Kwon-Soo Ha, Feng Lu, In-Bum Suh, Chae Seung Lim, Jeong Hyun Park, Satoru Takeo, Takafumi Tsuboi & Eun-Taek Han
Reference: 
Parasitology Research, Volume 109, Number 5, 1259-1266

MalariaWorldProtein arrays are powerful tools for antibody profiling and vaccine development against infectious agents. In the previous report, we successfully applied an antibody-based protein array for immunoprofiling of Plasmodium vivax infection.

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Trials for the co-expression of the merozoite surface protein-1 and circumsporozoite protein genes of Plasmodium vivax

October 19, 2011 - 06:51 -- Kabogo Ndegwa
Author(s): 
Choonghee Lee, Kyung Won Chung, Tong-Soo Kim, Kyung-Mi Choi, Yien Kyoung Choi, Nam-Jun Chung, Ho-Gun Rhie, Ho-Sa Lee, Sung-Jae Lee, Hyeong-Woo Lee
Reference: 
Experimental Parasitology, Volume 129, Issue 3, November 2011, Pages 227-23

MalariaWorldMerozoite surface protein-1 (MSP-1), a major asexual blood stage antigen, and circumsporozoite protein (CSP), a component of sporozoites that includes a Plasmodium vivax B-cell epitope, are strong candidates for use in a malaria vaccine.

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Immune responses elicited by co-immunization of Plasmodium vivax and P. falciparum MSP-1 using prime-boost immunization strategies

October 17, 2011 - 09:25 -- Kabogo Ndegwa
Author(s): 
A. A. Mehrizi, S. Zakeri, S. Rafati, A. H. Salmanian, N. D. Djadid
Reference: 
Parasite Immunology, Volume 33, Issue 11, pages 594–608, November 2011

MalariaWorldCarboxy-terminus of merozoite surface protein-1 (MSP-119) is the major protein on the surface of the plasmodial merozoite that acts as one of the most important blood-stage vaccine candidates.

Open Access | Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

October 11, 2011 - 06:56 -- Kabogo Ndegwa
Author(s): 
Somsak V, Uthaipibull C, Prommana P, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S
Reference: 
Malaria Journal 2011, 10:291 (7 October 2011)

MalariaWorldWith the permanent integration of Pvdhfr-ts gene in the genome, the transgenic Plasmodium lines expressing PvDHFR-TS are genetically stable and will be useful for screening anti-P. vivax compounds targeting PvDHFR-TS.

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Open Access | Identification of Plasmodium vivax Proteins with Potential Role in Invasion Using Sequence Redundancy Reduction and Profile Hidden Markov Models

October 11, 2011 - 06:43 -- Kabogo Ndegwa
Author(s): 
Daniel Restrepo-Montoya, David Becerra, Juan G. Carvajal-Patiño, Alvaro Mongui, Luis F. Niño, Manuel E. Patarroyo, Manuel A. Patarroyo
Reference: 
PLoS ONE 6(10): e25189

MalariaWorldThe results support the idea that probabilistic techniques like profile HMMs improve similarity searches.

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Evaluation of four rapid diagnostic tests for the diagnosis of Plasmodium vivax in Korea

October 11, 2011 - 06:39 -- Kabogo Ndegwa
Author(s): 
Kyung Hee Kim, Jin Woo Jang, Mi Kyung Woo, Jun Seo Oh, Eun Taek Han, Won Ja Lee, Seong Soo A. An and Chae Seung Lim
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 11, pages 1427–1431, November 2011

MalariaWorldThe performances of all four malaria RDT kits were acceptable, although Humasis Malaria P.f/Pan antigen test and CareStartTM Malaria Pf/Pv Combo test gave superior performances with ROK isolates.

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Short Report: HMS-Related Hemolysis after Acute Attacks of Plasmodium vivax Malaria

October 10, 2011 - 08:36 -- Patrick Sampao
Author(s): 
Oriol Mitjà, Russell Hays, James Malken, Anthony Ipai, Samson Kangapu, Jenny Robson and Quique Bassat
Reference: 
Am J Trop Med Hyg 2011 85:616-618

MalariaWorldAmong a cohort of 1,213 cases treated for Plasmodium vivax malaria from an isolated Papua New Guinean population, seven adults with severe and sustained hemolytic anemia after clearance of the peripheral parasitemia were prospectively investigated.

Open Access | Letter: Plasmodium vivax Seroprevalence in Bred Cynomolgus Monkeys, China

October 6, 2011 - 10:26 -- Patrick Sampao
Author(s): 
David B. Elmore
Reference: 
Emerging Infectious Diseases, ,Volume 17, Number 10—October 2011

MalariaWorldHaving worked with numerous species of research nonhuman primates over the past 26 years, I have a keen interest in related occupational health and safety.

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A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax

October 4, 2011 - 06:32 -- Kabogo Ndegwa
Author(s): 
Bruce Russell, Rossarin Suwanarusk, Laurent Rénia, et al.
Reference: 
Blood September 29, 2011 vol. 118 no. 13 e74-e81

MalariaWorldCurrently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America.

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Open Access | A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes

September 29, 2011 - 08:03 -- Kabogo Ndegwa
Author(s): 
Celine Barnadas, David Kent, Lincoln Timinao, Jonah Iga, Laurie R Gray, Peter Siba, Ivo Mueller, Peter J Thomas, Peter A Zimmerman
Reference: 
Malaria Journal 2011, 10:282 (24 September 2011)

MalariaWorldThe LDR-FMA described here allows a discriminant genotyping of resistance alleles in the pvdhfr, pvdhps, and pvmdr1 genes and can be used in large-scale surveillance studies.

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