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Plasmodium vivax

Open Access | Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure

January 12, 2012 - 07:56 -- Kabogo Ndegwa
Author(s): 
Mallick PK, Joshi H, Valecha N, Sharma SK, Eapen A, Bhatt RM, Srivastava HC, Sutton PL, Dash AP, Bhasin VK
Reference: 
Malaria Journal 2012, 11:16 (11 January 2012)

MalariaWorldThe wild type pfcrt gene is linked to chloroquine sensitivity; however, presence of mutation cannot explain the therapeutic efficacy of CQ in the current scenario of chloroquine resistance.

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Open Access | Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination

January 12, 2012 - 07:47 -- Kabogo Ndegwa
Author(s): 
Arnott A, Barry AE, Reeder JC
Reference: 
Malaria Journal 2012, 11:14 (10 January 2012)

MalariaWorldTraditionally, infection with Plasmodium vivax was thought to be benign and self-limiting, however, recent evidence has demonstrated that infection with P. vivax can also result in severe illness and death.

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Design and Immunogenicity of a Novel Synthetic Antigen Based on the Ligand Domain of the Plasmodium vivax Duffy Binding Protein

January 3, 2012 - 08:51 -- Kabogo Ndegwa
Author(s): 
Francis B. Ntumngia and John H. Adams
Reference: 
Clin Vaccine Immunol January 2012 vol. 19 no. 1 30-36

MalariaWorldThe Duffy binding protein is considered a leading vaccine candidate against asexual blood-stage Plasmodium vivax.

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Open Access | The Use of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium vivax Malaria

December 29, 2011 - 07:37 -- Kabogo Ndegwa
Author(s): 
Quique Bassat
Reference: 
PLoS Negl Trop Dis 5(12): e1325

MalariaWorldThe long-standing dearth of knowledge surrounding Plasmodium vivax, the most widely distributed of the malaria species, merits urgent attention.

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Open Access | Global host metabolic response to Plasmodium vivax infection: a 1H NMR based urinary metabonomic study

December 28, 2011 - 07:03 -- Kabogo Ndegwa
Author(s): 
Sengupta A, Ghosh S, Basant A, Malusare S, Johri P, Pathak S, Sharma S, Sonawat HM
Reference: 
Malaria Journal 2011, 10:384 (23 December 2011)

MalariaWorldThe results open up a possibility of non-invasive analysis and diagnosis of P. vivax using urine metabolic profile.

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Open Access | Spleen rates and infant parasite rates as surveillance tool for malaria control in remote hard to reach areas of central India

December 28, 2011 - 06:42 -- Kabogo Ndegwa
Author(s): 
Shukla M, Singh N, Singh MP
Reference: 
Malaria Journal 2011, 10:381 (21 December 2011)

MalariaWorldBoth the tools are of immense value in evaluating and assessing the malaria situation especially in remote areas where sophisticated molecular and serological techniques are difficult to establish.

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Open Access | Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America

December 21, 2011 - 11:06 -- Kabogo Ndegwa
Author(s): 
Jovel IT, Mejia RE, Banegas E, Piedade R, Alger J, Fontecha G, Ferrreira PE, Veiga MI, Enamorado IG, Bjorkman A, Ursing J
Reference: 
Malaria Journal 2011, 10:376 (19 December 2011)

MalariaWorldThe results indicate that P. falciparum from Honduras remain sensitive to chloroquine and sulphadoxine-pyrimethamine.

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Open Access | Plasmodium vivax lineages: geographical distribution, tandem repeat polymorphism, and phylogenetic relationship

December 21, 2011 - 10:14 -- Kabogo Ndegwa
Author(s): 
Prajapati SK, Joshi H, Shalini S, Patarroyo MA, Suwanarusk R, Kumar A, Sharma SK, Eapen A, Dev V, Bhatt RM, Valecha N, Nosten F, Rizvi MA, Dash AP
Reference: 
Malaria Journal 2011, 10:374 (19 December 2011)

MalariaWorldThe global lineage distribution, lack of genetic distance, similar pattern of genetic diversity, and allele sharing strongly suggested that both lineages are a single species and thus new emerging phenotypes associated with vivax malaria could not be clearly classified as belonging to a particular lineage on basis of their geographical origin.

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Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

December 20, 2011 - 09:37 -- Kabogo Ndegwa
Author(s): 
Luciane Moreno Storti-Melo, Daniela Reis da Costa, Ricardo Luiz Dantas Machado, et al.
Reference: 
Acta Tropica, Volume 121, Issue 2, February 2012, Pages 152-155

MalariaWorldWe evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil.

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Molecular assessment of dhfr/dhps mutations among Plasmodium vivax clinical isolates after introduction of sulfadoxine/pyrimethamine in combination with artesunate in Iran

December 16, 2011 - 14:30 -- Patrick Sampao
Author(s): 
Mandana Afsharpad, Sedigheh Zakeri, Sakineh Pirahmadi, Navid D. Djadid
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 1, January 2012, Pages 38-44

MalariaWorldIn conclusion, the present results suggest that SP could be effective in treatment against the erythrocytic stages of vivax malaria in Iran; however, the increased frequency of mutant haplotypes in Iran since 2006 is worrying and indicates the emergence of drug-tolerant/resistant P. vivax isolates in Iran in near future.

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