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Plasmodium vivax

Comparative genomic analysis of simple sequence repeats in three Plasmodium species

January 28, 2011 - 08:16 -- Kabogo Ndegwa
Author(s): 
Suchi Tyagi, Meenu Sharma & Aparup Das
Reference: 
Parasitology Research, Volume 108, Number 2, 451-458

Simple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution.

Open Access | A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies

January 27, 2011 - 09:47 -- Kabogo Ndegwa
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Author(s): 
The malERA Consultative Group on Basic Science and Enabling Technologies
Reference: 
PLoS Med 8(1): e1000399

Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite.

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Open Access | Exploring provider and community responses to the new malaria diagnostic and treatment regime in Solomon Islands

January 12, 2011 - 10:36 -- Kabogo Ndegwa
Author(s): 
Wijesinghe RS, Atkinson JM, Bobogare A, Wini L, Whittaker M
Reference: 
Malaria Journal 2011, 10:3 (10 January 2011)

To address these issues, further training and supportive supervision of healthcare workers will be essential, as will the engagement of influential community members in health promotion activities to improve acceptability of RDTs and adherence to the new treatment regime.

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Study of the Genetic Discrimination Between Imported and Autochthonous Cases of Malaria in South Korea

January 7, 2011 - 08:04 -- Kabogo Ndegwa
Author(s): 
Kyung Mi Choi, Yien Kyoung Choi, Young A. Kang, Soon Young Seo, Hyeong Woo Lee, Shin Hyeong Cho, Won Ja Lee, Ho Gun Rhie, Ho Sa Lee and Jung Yeon Kim
Reference: 
Journal of Travel Medicine, Volume 18, Issue 1, pages 63–66, January/February 2011

There has been a great increase of Plasmodium vivax incidences in the Republic of Korea and the genetic diversity of the parasite became more complex with the rapid dissemination of newly introduced genotypes.

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Plasmodium vivax: Prevalence of mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium vivax clinical isolates from Pakistan

January 3, 2011 - 09:06 -- Kabogo Ndegwa
Author(s): 
Sedigheh Zakeri, Mandana Afsharpad, Faezeh Ghasemi, Ahmad Raeisi, Qutbuddin Kakar, Hoda Atta, Navid Dinparast Djadid
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 167-172

The main aim of the present study was to investigate the frequency of SNPs-haplotypes of dhfr and dhps genes associated to sulfadoxine–pyrimethamine (SP) resistance in Plasmodium vivax clinical isolates circulating in a malaria endemic area, Pakistan.

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Open Access | Giemsa-stained thick blood films as a source of DNA for Plasmodium species-specific real-time PCR

December 23, 2010 - 14:04 -- Kabogo Ndegwa
Author(s): 
Cnops L, Van Esbroeck M, Bottieau E, Jacobs J
Reference: 
Malaria Journal 2010, 9:370 (22 December 2010)

Giemsa-stained TBFs are a reliable source of DNA for Plasmodium real-time PCR analysis, allowing applications in reference and research settings in case whole blood samples are not available.

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Unresolved direction of host transfer of Plasmodium vivax v. P. simium and P. malariae v. P. brasilianum

December 20, 2010 - 09:34 -- Patrick Sampao
Author(s): 
Loubna Tazi, Francisco J. Ayala
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 1, January 2011, Pages 209-221

Here, we investigate the phylogenies, haplotype networks, positive selection and genetic diversity among these parasite species by means of four genes. Human P. vivax and primate P. simium recently derived one from the other; at least two host transfers have occurred. Human P. malariae and primate P. brasilianum also have recently derived one from the other by lateral host transfer.

Genetic diversity and recombination at the C-terminal fragment of the merozoite surface protein-1 of Plasmodium vivax (PvMSP-1) in Sri Lanka

December 20, 2010 - 09:06 -- Patrick Sampao
Author(s): 
Sajani Dias, Shirley Longacre, Ananias A. Escalante, Preethi V. Udagama-Randeniya
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 1, January 2011, Pages 145-156

Here we investigated the level of genetic diversity in the PvMSP-142 gene fragment in 95 single clone P. vivax infections in Sri Lanka.

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Evaluation of the antigenicity of universal epitopes from PvDBPII in individuals exposed to Plasmodium vivax malaria

December 7, 2010 - 05:49 -- Patrick Sampao
Author(s): 
Paola Martinez, Carolina Lopez, Carolina Saravia, Magnolia Vanegas, Manuel A. Patarroyo
Reference: 
Microbes and Infection, Volume 12, Issues 14-15, December 2010, Pages 1188-1197

The results suggest that conserved peptides binding with high activity to red blood cells and with known affinity to HLA-DR proteins could be good components for a P. vivax vaccine.

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Limited Polymorphism of the Plasmodium vivax Merozoite Surface Protein 1 Gene in Isolates from Turkey

December 3, 2010 - 07:35 -- Patrick Sampao
Author(s): 
Fadile Yildiz Zeyrek., Shin-Ichiro Tachibana., Kazuyuki Tanabe., et al.
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1230 - 1237.

Data suggest a recent population bottleneck in Turkey that may have obscured a signature for balancing selection in the C-terminal 42-kD region, which was otherwise detectable in other areas.

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