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Plasmodium vivax

Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51.

February 17, 2011 - 14:51 -- Patrick Sampao
Author(s): 
Herrera S, Fernández OL, Vera O, Cárdenas W, Ramírez O, Palacios R, Chen-Mok M, Corradin G, Arévalo-Herrera M.
Reference: 
Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):12-20.

We assessed the safety, tolerability, and immunogenicity of a mixture of three synthetic peptides derived from the Plasmodium vivax circumsporozoite protein formulated in Montanide ISA 720 or Montanide ISA 51.

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Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.

February 17, 2011 - 14:05 -- Patrick Sampao
Author(s): 
Herrera S, Solarte Y, Jordán-Villegas A, Echavarría JF, Rocha L, Palacios R, Ramírez O, Vélez JD, Epstein JE, Richie TL, Arévalo-Herrera M.
Reference: 
Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):4-11.

Clinical manifestations of malaria and parasitemia were monitored beginning 7 days post-challenge. All Duffy (+) volunteers developed patent malaria infection within 16 days after challenge.

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Evaluation of the naturally acquired antibody immune response to the Pv200L N-terminal fragment of Plasmodium vivax merozoite surface protein-1 in four areas of the Amazon Region of Brazil.

February 17, 2011 - 13:06 -- Patrick Sampao
Author(s): 
Storti-Melo LM., Souza-Neiras WC., Machado RL ., et al
Reference: 
Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):58-63.

Results of this study provide evidence that Pv200L is a naturally immunogenic fragment of the PvMSP-1 and is associated with the degree of exposure to parasites.

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Open Access | Short-Lived IFN-γ Effector Responses, but Long-Lived IL-10 Memory Responses, to Malaria in an Area of Low Malaria Endemicity

February 15, 2011 - 08:58 -- Kabogo Ndegwa
Author(s): 
Jiraprapa Wipasa, Lucy Okell, Supachai Sakkhachornphop, Chaisuree Suphavilai, Kriangkrai Chawansuntati, Witaya Liewsaree, Julius C. R. Hafalla, Eleanor M. Riley
Reference: 
PLoS Pathog 7(2): e1001281

Immunity to malaria is widely believed to wane in the absence of reinfection, but direct evidence for the presence or absence of durable immunological memory to malaria is limited.

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Open Access | Cost-effectiveness of three malaria treatment strategies in rural Tigray, Ethiopia where both Plasmodium falciparum and Plasmodium vivax co-dominate

February 10, 2011 - 08:51 -- Patrick Sampao
Author(s): 
Hailemariam Lemma, Miguel San Sebastian, Curt Lofgren and GebreAb Barnabas
Reference: 
Cost Effectiveness and Resource Allocation 2011, 9:2

This study showed that the parascreen pan/pf based strategy should be the preferred option to be used at health post level in rural Tigray. This finding is relevant nationwide as the entire country's malaria epidemiology is similar to the study area.

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B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax Merozoite Surface Protein-3α (PvMSP-3α) in malaria exposed individuals from Brazilian Amazon

February 7, 2011 - 09:12 -- Patrick Sampao
Author(s): 
J.C. Lima-Junior., J. Jiang., Oliveira-Ferreira., et al
Reference: 
Vaccine, Volume 29, Issue 9, 17 February 2011, Pages 1801-1811

Our results indicates that PvMSP3 is highly immunogenic in naturally exposed populations, where 78% of studied individuals present IgG immune response against the full-length recombinant protein (PVMSP3-FL) and IgG subclass profile was similar to all five recombinant proteins studied with a high predominance of IgG1 and IgG3.

Open Access | Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy Binding Protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines

February 4, 2011 - 08:03 -- Patrick Sampao
Author(s): 
Bolton MJ, Garry RF
Reference: 
Virology Journal 2011, 8:45 (31 January 2011)

Variable loop 3 (V3) of HIV-1 SU and subdomain 1 of the Plasmodium vivax DBP share a sequence similarity. The site of amino acid sequence similarity was necessary, but not sufficient, for DARC binding and contained a consensus heparin binding site essential for DARC binding. Both HIV-1 and P. vivax can be blocked from binding to their chemokine receptors by the chemokine, RANTES and its analog AOP-RANTES.

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Open Access | Detection of an antibody against Plasmodium vivax in residents of Gimpo-si, South Korea, using an indirect fluorescent antibody test

February 4, 2011 - 07:12 -- Kabogo Ndegwa
Author(s): 
Lee W, Kim H, Hwang S, Park M, Kim N, Cho S, In T, Kim J, Sattabongkot J, Sohn Y, Kim H, Lee J, Lee H
Reference: 
Malaria Journal 2011, 10:19 (31 January 2011)

These results indicate that antibody titers obtained using IFAT may provide useful information about the prevalence of P. vivax in low endemic areas and could be used to detect asymptomatic patients. Finding asymptomatic patients is important in eliminating vivax malaria in South Korea.

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Open Access | Plasmodium vivax Sub-Patent Infections after Radical Treatment Are Common in Peruvian Patients: Results of a 1-Year Prospective Cohort Study

February 2, 2011 - 07:10 -- Kabogo Ndegwa
Author(s): 
Peter Van den Eede, Veronica E. Soto-Calle, Christopher Delgado, Dionicia Gamboa, Tanilu Grande, Hugo Rodriguez, Alejandro Llanos-Cuentas, Jozef Anné, Umberto D'Alessandro, Annette Erhart
Reference: 
PLoS ONE 6(1): e16257

In Peru, the P. vivax recurrent infections were common and displayed a high turnover of parasite genotypes compared to day 0.

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Open Access | Plasmodium vivax Tryptophan-Rich Antigen PvTRAg33.5 Contains Alpha Helical Structure and Multidomain Architecture

February 2, 2011 - 06:35 -- Kabogo Ndegwa
Author(s): 
Hema Bora, Sheena Garg, Priyankar Sen, Deepak Kumar, Punit Kaur, Rizwan Hasan Khan, Yagya D. Sharma
Reference: 
PLoS ONE 6(1): e16294

Tryptophan-rich proteins from several malarial parasites have been identified where they play an important role in host-parasite interaction.

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