The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10520 malaria professionals are enjoying the free benefits of MalariaWorld today

Plasmodium vivax

Molecular cloning and expression of the VK247 circumsporozoite protein for serodiagnosis of variant form Plasmodium vivax

April 20, 2011 - 08:03 -- Kabogo Ndegwa
Author(s): 
Tong-Soo Kim, Hyung-Hwan Kim, Sun-Sim Lee, Chang-Mi Oh, Kyung-Mi Choi, Khin Lin, Jung-Yeon Kim, Byoung-Kuk Na, Eun-Taek Han, Youngjoo Sohn, Hyuck Kim & Hyeong-Woo Lee
Reference: 
Parasitology Research, Volume 108, Number 5, 1275-1282

Plasmodium vivax is classified into two serotypes, VK210 [the dominant form- GDRA(D/A)GQPA repeats] and VK247 [the variant form-ANGA(G/D)(N/D)QPG repeats], based on sequence variation of the repeat region of the circumsporozoite (CS) protein gene.

Technology: 
Medical Condition: 

Review: The State of the Art in Anti-Malarial Drug Discovery and Development

April 19, 2011 - 14:52 -- Patrick Sampao
Author(s): 
N. Burrows, Jeremy; Chibale, Kelly; N.C. Wells, Timothy
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 10, May 2011 , pp. 1226-1254(29)

This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches being developed as a contribution towards the malaria eradication agenda.

Medical Treatment: 

Plasmodium vivax: Collaborative roles for plasmepsin 4 and vivapains in hemoglobin hydrolysis

April 14, 2011 - 12:53 -- Kabogo Ndegwa
Author(s): 
Sung-Ung Moon, Jung-Mi Kang, Tong-Soo Kim, Yoon Kong, Woon-Mok Sohn, Byoung-Kuk Na
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 127-132

Plasmepsins, a family of aspartic proteases of Plasmodium species, are known to participate in a wide variety of cellular processes essential for parasite survival.

Open Access | Prevalence of molecular markers of anti-malarial drug resistance in Plasmodium vivax and Plasmodium falciparum in two districts of Nepal

April 5, 2011 - 09:12 -- Kabogo Ndegwa
Author(s): 
Ranjitkar S, Schousboe ML, Thomsen TT, Adhikari M, Kapel CM, Bygbjerg IC, Alifrangis M
Reference: 
Malaria Journal 2011, 10:75 (1 April 2011)

Based on the limited number of samples, prevalence of CQ and SP resistance at molecular levels in the population in the study area were determined as high in P. falciparum and low in P. vivax.

Country: 

Short Report: Therapeutic Efficacy of Chloroquine in Plasmodium vivax and the pvmdr1 Polymorphisms in the Republic of Korea Under Mass Chemoprophylaxis

April 4, 2011 - 14:13 -- Patrick Sampao
Author(s): 
Young Keun Kim, Changsoo Kim, Inho Park, Hyo Youl Kim, Jun Yong Choi, AND June Myung Kim
Reference: 
Am J Trop Med Hyg, Apr 2011; 84: 532 - 534.

We investigated the therapeutic efficacy of HCQ and the pvmdr1 gene polymorphisms in P. vivax. From June to September 2006, 102 soldiers with vivax malaria near the demilitarized zone in Gyeonggi-do, ROK, were enrolled in the study.

Technology: 
Medical Condition: 
Medical Treatment: 

Open Access | PvRON2, a new Plasmodium vivax rhoptry neck antigen

March 15, 2011 - 08:57 -- Kabogo Ndegwa
Author(s): 
Arevalo-Pinzon G, Curtidor H, Patino LC, Patarroyo MA
Reference: 
Malaria Journal 2011, 10:60 (14 March 2011)

The identification and partial characterization of the first P. vivax rhoptry neck protein are described in the present study.

Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine

March 9, 2011 - 08:38 -- Patrick Sampao
Author(s): 
Takeshi Miyata., Tetsuya Harakuni., Takeshi Arakawa., et al.
Reference: 
Vaccine, Volume 29, Issue 15, 24 March 2011, Pages 2720-2726

This study, the first preclinical evaluation of adenovirus-vectored malaria OSPs, implicates a potential inclusion of malaria transmission-blocking vaccine antigens in viral vector systems.

Medical Treatment: 

Short Communication: Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

March 1, 2011 - 08:01 -- Patrick Sampao
Author(s): 
Diego Garzón-Ospina, Liza Romero-Murillo, Luisa F. Tobón, Manuel A. Patarroyo
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 528-531

Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity.

Country: 
Medical Condition: 
Medical Treatment: 

High-throughput molecular diagnosis of circumsporozoite variants VK210 and VK247 detects complex Plasmodium vivax infections in malaria endemic populations in Papua New Guinea

March 1, 2011 - 07:44 -- Patrick Sampao
Author(s): 
Cara N. Henry-Halldin, Daphne Sepe, Melinda Susapu, David T. McNamara, Moses Bockarie, Christopher L. King, Peter A. Zimmerman
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 391-398

Overall, our results illustrate that PNG malaria-endemic regions harbor a complex mixture of P. vivax strains, and emphasize the importance of malaria control strategies that would be effective against a highly diverse parasite population.

The Presence of Leukocytes in Ex Vivo Assays Significantly Increases the 50-Percent Inhibitory Concentrations of Artesunate and Chloroquine against Plasmodium vivax and Plasmodium falciparum

March 1, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
S. Kaewpongsri, K. Sriprawat, R. Suwanarusk, D. E. Kyle, U. Lek-Uthai, M. Leimanis, K. M. Lwin, A. P. Phyo, J. Zwang, B. Russell, F. Nosten, and L. Renia
Reference: 
Antimicrobial Agents and Chemotherapy, March 2011, p. 1300-1304, Vol. 55, No. 3

Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing.

Medical Treatment: 

Pages

Subscribe to RSS - Plasmodium vivax