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Plasmodium vivax

NOT Open Access | Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase-Deficient Malaria Patient in Southeastern Bangladesh

November 12, 2019 - 16:16 -- NOT Open Access
Author(s): 
Phru CS, Kibria MG, Thriemer K, Chowdhury MU, Jahan N, Aktaruzzaman MM, Rahmat H, Satyagraha AW, Prue AS, Khan WA, Ley B, Alam MS.
Reference: 
Am J Trop Med Hyg. 2019 Nov 4

We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated Plasmodium vivax infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days.

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Killing of Plasmodium vivax by Primaquine and Tafenoquine

October 30, 2019 - 09:45 -- Open Access
Author(s): 
Miles B. Markus
Reference: 
Trends In Parasitology, Volume 35, ISSUE 11, P857-859, November 01, 2019

Primaquine administration results in H 2O 2 accumulation in bone marrow, where gametocytes and asexual parasites are therefore killed. This finding, by Camarda et al. , supports the theory that the nonperipheral blood origin of recurrent Plasmodium vivax malaria is both hypnozoites (relapse source) and merozoites (recrudescence source), not hypnozoites only.

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Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India

September 30, 2019 - 13:35 -- Open Access
Author(s): 
Prabhanjan P. Gai, Welmoed van Loon, Frank P. Mockenhaupt, et al.
Reference: 
Malaria Journal 2019 18:328, 24 September 2019

Duffy blood group antigens serve as receptors for Plasmodium vivax invasion into erythrocytes, and they are determined by polymorphisms of the Duffy antigen receptor for chemokines (DARC), also known as Fy glycoprotein (FY). Duffy negativity, i.e., absence of the antigens, protects against P. vivax infection and is rare among non-African populations. However, data on DARC polymorphisms and their impact on Plasmodium infection in India are scarce.

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A retrospective analysis on the transmission of Plasmodium falciparum and Plasmodium vivax: the case of Adama City, East Shoa Zone, Oromia, Ethiopia

June 11, 2019 - 14:49 -- Open Access
Author(s): 
Temesgen File, Hunduma Dinka and Lemu Golassa
Reference: 
Malaria Journal 2019 18:193, 11 June 2019

Malaria is more often considered a problem of the rural poor and the disease has been overlooked in urban settings for centuries due to the assumption that economic development in urban areas results in better life conditions, such as improved housing, drainage system and environmental changes that makes urban areas not conducive for breeding of the malaria vector. But, for many African countries, including Ethiopia, in most urban areas, although there are rapid developments, they are characterized by poor housing, lack of sanitation and drainage of surface water that would provide favourable conditions for vector breeding. Limited studies have been conducted as far as urban malaria is concerned in Ethiopia. The purpose of this study was to assess the status of falciparum and vivax malaria transmission in Adama City, Eastern Shoa Zone, Oromia, Ethiopia. Understanding the local epidemiology of malaria will help policy makers and other stakeholders to design and implement tailored cost effective and efficient intervention strategies targeting urban malaria.

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Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

November 7, 2018 - 15:10 -- Open Access
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Author(s): 
Jonathan Berman, Tracey Brown, Geoffrey Dow and Stephen Toovey
Reference: 
Malaria Journal 2018 17:407, 6 November 2018

Extrapolation of data from Rhesus monkeys to humans, and the available clinical data, suggest that tafenoquine also does not exhibit pamaquine, pentaquine or plasmocid-like clinical neurologic signs in humans.

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Adaptive Evolution of RH5 in Ape Plasmodium species of the Laverania Subgenus

March 13, 2018 - 13:37 -- Open Access
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Author(s): 
Lindsey J. Plenderleith, Weimin Liu, Paul M. Sharp, et al.
Reference: 
mBio January/February 2018 9:e02237-17

Plasmodium falciparum, the major cause of malaria morbidity and mortality in humans, has been shown to have emerged after cross-species transmission of one of six host-specific parasites (subgenus Laverania) infecting wild chimpanzees (Pan troglodytes) and western gorillas (Gorilla gorilla).

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G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon

June 15, 2017 - 15:43 -- Open Access
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Author(s): 
Jamille G. Dombrowski, Rodrigo M. Souza, Claudio R. F. Marinho, et al.
Reference: 
Malaria Journal 2017 16:253, 15 June 2017

The data indicates that ~1/23 males from the Alto do Juruá could be G6PD deficient and at risk of haemolytic anaemia if treated with primaquine.

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Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar

April 11, 2017 - 15:34 -- Open Access
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Author(s): 
Myo Thiha Zaw, Myo Thant, Jetsumon Sattabongkot, et al.
Reference: 
Malaria Journal 2017 16:138, 4 April 2017

A combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area.

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Malaria elimination challenges in Mesoamerica: evidence of submicroscopic malaria reservoirs in Guatemala

September 3, 2016 - 16:33 -- Open Access
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Author(s): 
Shirley Evelyn Lennon, Adolfo Miranda, Juliana Henao, Andres F. Vallejo, Julianh Perez, Alvaro Alvarez, Myriam Arévalo-Herrera and Sócrates Herrera
Reference: 
Malaria Journal 2016 15:441, 30 August 2016

This study found a considerable number of asymptomatic P. vivax infections that were mostly submicroscopic, of which, approximately one-quarter harboured mature gametocytes.

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Diagnosis of an imported Plasmodium ovale wallikeri infection in Malaysia

January 12, 2016 - 16:50 -- Open Access
Author(s): 
Jonathan Liew, Rohela Mahmud, Lian Tan, Yee Lau
Reference: 
Malaria Journal 2016, 15:8 (6 January 2016)

Plasmodium ovale is rare and not exactly known to be autochthonous in Malaysia.

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