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Plasmodium

A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents

July 27, 2016 - 06:59 -- Open Access
Author(s): 
Noemí Bahamontes-Rosa, María G. Gomez-Lorenzo, Joël Lelièvre, Ane Rodriguez Alejandre, María Jesus Almela, Sonia Lozano, Esperanza Herreros and Francisco-Javier Gamo
Reference: 
Malaria Journal 2016 15:385, 22 July 2016

This study describes a novel assay for characterizing the activity of anti-malarial drugs against the later stages of P. falciparum gametocyte development using qPCR in genetically unmodified parasites.

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Not Open Access | Differential carbonylation of cytoskeletal proteins in blood group O erythrocytes: Potential role in protection against severe malaria

November 12, 2012 - 15:09 -- NOT Open Access
Author(s): 
Darío Méndez, María L. Hernáez, Ali N. Kamali, AmaliaDiez, Antonio Puyet, José M. Bautista
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1780-1787
MalariaWorld

Through redox proteomics, we detected differences in carbonylated membrane proteins among the different blood groups, both in Plasmodium-infected and uninfected erythrocytes (RBC).

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The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium

October 23, 2012 - 11:00 -- Patrick Sampao
Author(s): 
Robert E. Sinden, Andrew M. Blagborough, Thomas Churcher, Chandra Ramakrishnan, Sumi Biswas, Michael J. Delves
Reference: 
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 457-465

MalariaWorldHere we attempt to identify the utility of each assay and provide rational frameworks by which to compare the impacts recorded by the diverse methodologies.

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A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion

October 1, 2012 - 08:00 -- Kabogo Ndegwa
Author(s): 
David S. Guttery, Benoit Poulin, Rita Tewari, et al.
Reference: 
PLoS Pathog 8(9): e1002948

MalariaWorldProtein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological conditions in humans.

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A Unique Kelch Domain Phosphatase in Plasmodium Regulates Ookinete Morphology, Motility and Invasion

September 7, 2012 - 07:45 -- Kabogo Ndegwa
Author(s): 
Nisha Philip, Heli J. Vaikkinen, Laurence Tetley, Andrew P. Waters
Reference: 
PLoS ONE 7(9): e44617

MalariaWorldSignalling through post-translational modification (PTM) of proteins is a process central to cell homeostasis, development and responses to external stimuli.

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Not Open Access | Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite

August 22, 2012 - 14:58 -- Patrick Sampao
Author(s): 
Maya Kono, Susann Herrmann, Tim W. Gilberger, et al.
Reference: 
Mol Biol Evol (2012) 29 (9): 2113-2132

MalariaWorldIn this article, we present a comprehensive evolutionary analysis of IMC components, which exemplifies the adaptive nature of the IMCs' protein composition.

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Not Open Access | The Plasmodium Apicoplast Genome: Conserved Structure and Close Relationship of P. ovale to Rodent Malaria Parasites

August 22, 2012 - 14:36 -- Patrick Sampao
Author(s): 
Nobuko Arisue, Tetsuo Hashimoto, Hideya Mitsui, Nirianne M.Q. Palacpac, Akira Kaneko, Satoru Kawai, Masami Hasegawa, Kazuyuki Tanabe and Toshihiro Horii
Reference: 
Mol Biol Evol (2012) 29 (9): 2095-2099

MalariaWorldHere, we obtained the near-complete apicoplast genome sequences from eight Plasmodium species that infect a wide variety of vertebrate hosts and performed structural and phylogenetic analyses.

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Not Open Access | Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis

August 20, 2012 - 11:15 -- Patrick Sampao
Author(s): 
Matthew L. Jones, Mark O. Collins, David Goulding, Jyoti S. Choudhary, Julian C. Rayner
Reference: 
Cell Host & Microbe, Volume 12, Issue 2, 16 August 2012, Pages 246-258

MalariaWorldUsing complementary palmitoyl protein purification approaches and quantitative mass spectrometry, we examined protein palmitoylation in asexual-stage P. falciparum parasites and identified over 400 palmitoylated proteins, including those involved in cytoadherence, drug resistance, signaling, development, and invasion.

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NOT Open Access | Antimicrobials: Arming symbionts with antimalarials

August 16, 2012 - 08:11 -- Kabogo Ndegwa
Author(s): 
Christina Tobin Kåhrström
Reference: 
Nature Reviews Microbiology 10, 594-595 (September 2012)

MalariaWorldAs the frequencies of mosquito insecticide resistance and parasite drug resistance continue to rise, alternative strategies to curb the emergence and spread of malaria are urgently needed.

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