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severe malaria

An Antioxidant Link between Sickle Cell Disease and Severe Malaria

May 4, 2011 - 10:12 -- Kabogo Ndegwa
Author(s): 
Ashraful Haque, Christian R. Engwerda
Reference: 
Cell, Volume 145, Issue 3, 29 April 2011, Pages 335-336

Although a link between sickle cell disease and resistance to severe malaria is well established, the biochemical relationship between the two is unknown.

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Synopsis: Open Access | Synopsis: Intravenous Artesunate for Severe Malaria in Travelers, Europe

April 26, 2011 - 15:06 -- Patrick Sampao
Author(s): 
Thomas Zoller, Thomas Junghanss, Holger Flick, et al.
Reference: 
Emerging Infectious Diseases, Volume 17, Number 5–May 2011

Multicenter trials in Southeast Asia have shown better survival rates among patients with severe malaria, particularly those with high parasitemia levels, treated with intravenous (IV) artesunate than among those treated with quinine.

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Open Access | Case Management of Severe Malaria - A Forgotten Practice: Experiences from Health Facilities in Uganda

March 8, 2011 - 07:18 -- Kabogo Ndegwa
Author(s): 
Jane Achan, James Tibenderana, Daniel Kyabayinze, Henry Mawejje, Rukaaka Mugizi, Betty Mpeka, Ambrose Talisuna, Umberto D'Alessandro
Reference: 
PLoS ONE 6(3): e17053

Management of severe malaria in Ugandan health facilities was sub-optimal. These findings highlight the challenges of correctly managing severe malaria in resource limited settings.

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Open Access | A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland Papuan children and adults

November 3, 2010 - 06:48 -- Kabogo Ndegwa
Author(s): 
Randall LM, Kenangalem E, Engwerda CR, et al.
Reference: 
Malaria Journal 2010, 9:302 (29 October 2010)

These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.

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Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

June 22, 2010 - 09:47 -- Kabogo Ndegwa
Author(s): 
Bruno B. Andrade, Théo Araújo-Santos, Nívea F. Luz, Ricardo Khouri, Marcelo T. Bozza, Luís M. A. Camargo, Aldina Barral, Valéria M. Borges, and Manoel Barral-Netto
Reference: 
J Immunol published 18 June 2010, 10.4049/jimmunol.0904179

In many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses.

Clinical Microbiology: Severe Plasmodium malariae Malaria in a Patient With Multiple Susceptibility Genes (p 201-202)

April 22, 2010 - 11:59 -- Kabogo Ndegwa
Author(s): 
Anne-Pauline Bellanger, Fabrice Bruneel, Olivier Barbot, Jean-Paul Mira, Laurence Millon, Pascal Houzé, Jean-François Faucher, Sandrine Houzé
Reference: 
Journal of Travel Medicine, Volume 17 Issue 3, Pages 201 – 202

Our case suggests that P. malariae may cause life-threatening disease, and that disease severity may be linked, at least in part, to multiple susceptibility genes.

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Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

April 15, 2010 - 15:07 -- Patrick Sampao
Author(s): 
Chintana P., Collins O., et al.
Reference: 
Immunogenetics, Online first

Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional association between IL12B polymorphisms [i.e. IL12Bpro (rs17860508) and IL12B 3′ UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n = 355) recruited from malaria endemic areas along the Thai–Myanmar border in northwest Thailand.

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Open Access | Further Evidence Supporting a Role for Gs Signal Transduction in Severe Malaria Pathogenesis

April 8, 2010 - 12:56 -- Kabogo Ndegwa
Author(s): 
Sarah Auburn, Andrew E. Fry, Taane G. Clark, Susana Campino, Mahamadou Diakite, Angela Green, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Malcolm E. Molyneux, Terrie E. Taylor, Kasturi Haldar, Kirk A. Rockett, Dominic P. Kwiatkowski
Reference: 
PLoS ONE 5(4): e10017.

Having previously demonstrated a role for the G-alpha-s gene, GNAS, in severe malaria disease, we sought to identify other important components of the Gs pathway.

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The use of placebo in a trial of rectal artesunate as initial treatment for severe malaria patients en route to referral clinics: ethical issues

February 15, 2010 - 12:14 -- Ingeborg van Schayk
Author(s): 
Andrew Kitua, Peter Folb, Melba Gomes et al.
Reference: 
J. Med. Ethics. 2010; 36:116-120

Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities.

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A Simple Score to Predict the Outcome of Severe Malaria in Adults

February 11, 2010 - 08:40 -- Kabogo Ndegwa
Author(s): 
Josh Hanson, Sue J. Lee, Sanjib Mohanty, M. A. Faiz, Nicholas M. Anstey, Prakaykaew Charunwatthana, Emran Bin Yunus, Saroj K. Mishra, Emiliana Tjitra, Ric N. Price, Ridwanur Rahman, Francois Nosten, Ye Htut, Gofranul Hoque, Tran Thi Hong Chau, Nguyen Hoan Phu, Tran Tinh Hien, Nicholas J. White, Nicholas P. J. Day, and Arjen M. Dondorp
Reference: 
Clinical Infectious Diseases, Volume 50, Issue 5, Page 679–685, Mar 2010

World Health Organization treatment guidelines recommend that adults with severe malaria be admitted to an intensive care unit (ICU). However, ICU facilities are limited in the resource‐poor settings where most malaria occurs. 

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